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Department Chemie - Institute for Advanced Study
 
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Publications

668. J. Deeg, I. Louban, D. Aydin, C. Selhuber-Unkel, H. Kessler, J. Spatz, Impact of Local versus Global Ligand Density on Cellular Adhesion, Nano Letters 2011, 11(4), 1469-1476.

667. O. Ovadia, J. Chatterjee, B. Laufer, F. Opperer, H. Kessler, C. Gilon, A. Hoffman, The effect of multiple N-methylation on intestinal permeability of cyclic hexapeptides, Mol. Pharmaceutics, 2011, 8, 479-487.

666. C. Mas-Moruno, F. Rechenmacher, H. Kessler; Cilengitide: the first anti-angiogenic small molecule drug candidate Design, synthesis and clinical evaluation, Anti-Cancer Agents In Medicinal Chemistry 2011, 10, 753-768.

665. M. Amela-Cortes, V. Roullier, C. Wolpert, S. Neubauer, H. Kessler, O. Bedel, S. Mignani, V. Marchi-Artzner, Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry, Chemcomm 2011, 47, 1246-1248.

664. J. Fiedler, J. Groll, E. Engelhardt, P. Gasteier, C. Dahmen, H. Kessler, M. Moeller, R. E. Brenner, NCO-sP(EO-stat-PO) surface coatings preserve biochemical properties of RGD peptides, Int. J. Mol. Medicine 2011, 27, 139-146.

663. F. Hagn, C. Thamm, T. Scheibel, H. Kessler; pH Dependent Dimerisation and Salt Dependent Stabilisation of the N-terminal Domain of Spider Dragline Silk - Implications for Fibre Formation, Angew. Chem. Int. Ed. 2011, 50, 310-313.

 


662. S. Kruss, T. Wolfram, R. Martin, S. Neubauer, H. Kessler, J. P. Spatz, Stimulation of Cell Adhesion at Nanostructured Teflon Interfaces, Advanced Materials, 2010, 22, 5499-5506.

661. A. O. Frank, E. Otto, C. Mas-Moruno, H. B. Schiller, L. Marinelli, S. Cosconati, A. Bochen, D. Vossmeyer, G. Zahn, R. Stragies, E. Novellino, H. Kessler; Conformational Control of Integrin Subtype Selectivity in isoDGR Peptide Motifs: A Biological Switch, Angew. Chem. Int. Ed. 2010, 49, 9278-9281.

660. I. Varnay, V. Truffault, S. Djuranovic, A. Ursinus, M. Coles, H. Kessler; Optimized measurement temperature gives access to the solution structure of a 49 kDa homohexameric β propeller, J. Amer. Chem. Soc. 2010, 132, 15692-15698.

659. D. Aydin, I. Louban, N. Perschmann, J. Blümmel, T. Lohmüller, E. A. Cavalcanti-Adam, T.L. Haas, H. Walczak, H. Kessler, R. Fiammengo, J. P. Spatz, Polymeric Substrates with Tunable Elasticity and Nanoscopically Controlled Biomolecule Presentation, Langmuir, 2010, 26 (19), 15472-15480.

658. S. Welker, B. Rudolph, E. Frenzel, F. Hagn, G. Liebisch, G. Schmitz, J. Scheuring, A. Kerth, A. Blume, S. Weinkauf, M. Haslbeck, H. Kessler, J. Buchner; Hsp12 is an Intrinsically Unstructured Stress Protein which folds upon Membrane Association and Modulates Membrane Function, Mol. Cell, 2010, 39 (4), 507-520.

657. L. Doedens, F. Opperer, M. Cai, J. G. Beck, M. Dedek, E. Palmer, V. J. Hruby, H. Kessler, Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity; pharmacological and conformational studies, J. Amer. Chem. Soc. 2010, 132 (23), 8115-8128.

656. A. G. F. de Beer, E. A. Cavalcanti-Adam, G. Majer, M. Lopez-Garcia, H. Kessler, J. P. Spatz, Force induced destabilization of adhesion complexes at defined integrin spacings on nanostructured surfaces, Physical Review E 81 2010, 051914 (1-7).

655. O. Ovadia, S. Greenberg, B. Laufer, C. Gilon, A. Hofmann, H. Kessler, Improvement of Drug Like Properties of Peptides: The Somatostatin paradigm, Expert Opin. Drug Discov. 2010, 5(7), 655-671.

654. B. Laufer, A. O. Frank, J. Chatterjee, T. Neubauer, C. Mas-Moruno, G. Kummerlöwe, H. Kessler, The Impact of Amino Acid Side Chain Mutations in Conformational Design of Peptides and Proteins, Chemistry Eur. J. 2010, 16, 5385-5390.

653. F. Hagn, L. Eisoldt, J. Hardy, C. Vendrely, M. Coles, T. Scheibel, H. Kessler, A highly conserved spider silk domain acts as a molecular switch that controls fibre assembly, Nature 2010, 465, 239-242.

652. C. Selhuber-Unkel, T. Erdmanm, M. Lopez-Garcia, H. Kessler, U.S. Schwarz, J.P. Spatz, Cell Adhesion Strength is controlled by Intermolecucar Spacing of Adhesion Receptors, Biophys. J. 2010, 98, 543-551 (featured article).

651. M. Retzlaff, F. Hagn, L. Mitschke, M. Hessling, F. Gugel, H. Kessler, K. Richter, J. Buchner, Asymmetric activation of the Hsp90 dimer by its co-chaperone Aha1, Mol. Cell 2010, 37, 344-354.

650. F. Hagn, C. Klein, O. Demmer, N. Marchenko, U. M. Moll, H. Kessler, BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain, J. Biol. Chem. 2010, 285, 3439-3450.

649. K.-H. Altmann, J. Buchner, H. Kessler, F. Diederich, B. Kräutler, S. Lippard, R. Liskamp, K. Müller, E. M. Nolan, B. Samori, G. Schneider, S.L. Schreiber, H. Schwalbe, C. Toniolo, C. A. A. van Boeckel, H. Waldmann, C.T. Walsh, The State of Art of Chemical Biology, Chembiochem 2009, 15, 16-29.

 

648. M. Retzlaf, M. Stahl, H. C. Eberl, S. Lagleder, J. Beck, H. Kessler, J. Buchner, Hsp90 is regulated by a switch point in the C-terminal domain, EMBO Reports 2009, 10, 1147-1153.

647.  O. Demmer, A.O. Frank, H. Kessler, Design of Cyclic Peptides - in Peptide and Protein Design for Biopharmaceutical Applications, Ed. K. J. Jensen, Wiley, 2009, 133 - 176.

646. M. Hoefling, H. Kessler, K.-E. Gottschalk, The Transmembrane Structure of Integrin aIIbb3 - Significance to Signal Transduction, Angew. Chem. Int. Ed. 2009, 48, 6590-6593.

645. T. Huber, F. Manzenrieder, C. A. Kuttruff, C. Dorner-Ciossek, H. Kessler, Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of β-secretase (BACE1), Bioorg. Med. Chem. Lett. 2009, 19, 4427-4431.

644. M. J. Feige, S. Groscurth, M. Marcinowski, Y. Shimizu, H. Kessler, L. M. Hendershot, J. Buchner, An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies, Mol. Cell 2009, 34 (5), 569-579.

 

643. M. Schottelius, B. Laufer, H. Kessler, H.-J. Wester, Ligands for mapping avb3-integrin expression in vivo, Acc. Chem. Res. 2009, 42, 969-980.

642. O. Schnell, B. Krebs, J. Carlsen, I. Stangier, C. Goetz, R. H. Goldbrunner, H.-J. Wester, R. Haubner, G. Pöpperl, M. Holtmannspötter, H. Kessler, J.-C. Tonn, M. Schwaiger, A. J. Beer, Imaging of Integrin αvβ3 Expression in Patients with Malignant Glioma by [18F]Galacto-RGD Positron Emission Tomography, Neuro-Oncology, 2009, 11, 861-870.

 

641. M. Spichty, A. Taly, F. Hagn, H. Kessler, N. Winssinger, M. Karplus; The Hsp90 binding mode of a radicicol-like E-oxime from docking, binding free energy estimations, and NMR shifts; Biophys. Chem. 2009, 143, 111-123.

640. M. J. Pandya, H. Bendz, F. Manzenrieder, E. Noessner, H. Kessler, J. Buchner, R. D. Issels, Interaction of human heat shock protein 70 with tumour-associated peptides, Biological Chemistry 2009, 390, 305-312.

639. J.H. Huang, S.V. Graeter, F. Corbellini, S. Rinck, E. Bock, R. Kernkerner, H. Kessler, J.D. Ding, J.P. Spatz, Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion, Nanoletters 2009, 9, 1111-1116.

638. D. Heckmann, B. Laufer, L. Marinelli , V. Limongelli, E. Novellino, G. Zahn, R. Stragies, H. Kessler;  Breaking the dogma of carboxylate group as metal coordinating agent in integrin ligands: targeting of the MIDAS by hydroxamic acids to tune potency and selectivity; Angew. Chem. Int. Ed. 2009, ASAP.

637. M. Arnold, M. Schwieder, J. Blummel, E.A. Cavalcanti-Adam, M. Lopéz-García, H. Kessler, B. Geiger, J. Spatz, Soft Matter 2009, 5 (1), 72-77.

636. B. Laufer, J. Chatterjee, A. O. Frank, H. Kessler, Can N-Methylated Amino Acids Serve as Substitute for Prolines in Conformational Design of Cyclic Pentapeptides? , J. Pept. Sci. 2009, 15, 141-146.

635. C. Selhuber-Unkel, M. López-García, H. Kessler, J.P. Spatz, Cooperativity in Adhesion Cluster Formation during Initial Cell Adhesion, Biophys. J. 2008, 95, 5424-5431.

634. J. Klages, A. Kotzsch, M. Coles, J. Nickel, T. Müller, H. Kessler, The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding, Biochemistry 2008, 47, 11930-11939.

633. G. Kummerlöwe, S. Knör, A. Frank, T. Paululat, H. Kessler, B. Luy, Deuterated Polymer Gels for Measuring Anisotropic NMR Parameters with Strongly Reduced Artefacts, Chem. Commun. 2008, 5722-5724.

632. M. Pellecchia, I. Bertini, D. Cowburn, C. Dalvit, E. Giralt, W. Jahnke, T. L. James, S. W. Homans, H. Kessler, C. Luchinat, B. Meyer, H. Oschkinat, J. Peng, H. Schwalbe, G. Siegal. Perspectives on NMR in Drug Discovery: A Technique Comes of Age, Nat. Rev. Drug Disc. 2008, 7, 738-745.

631. A. Enthart, J. C. Freudenberger, J. Furrer, H. Kessler, B. Luy, The CLIP/CLAP-HSQC: Pure Absorptive Spectra for the Measurement of One-Bond Couplings, J. Magn. Res. 2008, 192 (2), 314-322.

630. M.J. Feige, S. Groscurth, M. Marcinowski, Z.T. Yew, V. Truffault, E. Paci, H. Kessler, J. Buchner, The structure of a folding intermediate explains differences in immunoglobulin amyloidogenicity, PNAS 2008, 105 (36), 13373-13378.

629. M. Arnold, V.C. Hirschfeld-Warneken, T. Lohmüller, P. Heil,  J. Blummel, E.A. Cavalcanti-Adam, M. Lopez-Garcia, P. Walther, H. Kessler, B. Geiger, J.P. Spatz, Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing, Nanoletters 2008, 8 (7), 2063-2069.

628. J. Chatterjee, C. Gilon, A. Hoffman, H. Kessler, N-Methylation of Peptides: A New Perspective in Medicinal Chemistry, Acc. Chem. Res. 2008, 41, 1331-1342.

627. D. Kaufmann, A. Fiedler, A. Junger, J. Auernheimer, H. Kessler, R. Weberskirch, Chemical conjugation of linear and cyclic RGD moieties to a recombinant elastin-mimetic polypeptide - A versatile approach towards bioactive protein hydrogels, Macromolecular Bioscience 2008, 8(6), 577-588.

626. O. Demmer, I. Dijkgraaf, M. Schottelius, H.-J. Wester, H.Kessler, Introduction of Functional Groups into Peptides via N-Alkylation, Org. Lett. 2008, 10 (10), 2015-2018.

625. S. Kalinina; H. Gliemann; M. Lopez-Garcia; J. Auernheimer; T.Schimmel; M. Bruns; A. Schambony; H. Kessler; D. Wedlich, Isothiocyanate-functionalized RGD-peptides as useful alternative in tailoring cell-adhesive surface patterns, Biomaterials 2008, 29, 3004-3013.

624. V. C. Hirschfeld-Warneken, M. Arnold, A. Cavalcanti-Adam, M. López-García, H. Kessler, J. P. Spatz, Cell Adhesion and Polarisation on Molecularly Defined Spacing Gradient Surfaces of Cyclic RGDfK Peptide Patches, Eur.J.Cell Biol. 2008, 87, 743-750.

623. D. Heckmann, A. Meyer, B. Laufer, G. Zahn, R. Stragies, H. Kessler, Rational Design of Highly Active and Selective Ligands for α5β1 Integrin Receptor, ChemBioChem. 2008, 9, 1397-1407.

622. A.O. Frank, H. Kessler, The sweetest candy for the virus, Nature (News and Views) 2008, 452 (April 17), 822-823.

621.  F. Manzenrieder, A. O. Frank, H. Kessler, Phosphorus NMR as Versatile Tool for Compound Library Screening, Angew.Chem Int. Ed. 2008, 47 (14), 2608-2611.

620. T. Higuchi, F.M. Bengel, S. Seidl, P. Watzlowik, H. Kessler, R. Hegenloh, S. Reder, S. G. Nekolla, H.-J. Wester, ; M. Schwaiger,  Assessment of αvβ3 Integrin Expression after Myocardial Infarction by Positron Emission Tomography, Cardiovasc. Res. 2008, 78, 395-403.

619. E. Biron, J. Chatterjee, O. Ovadia, D. Langenegger, J. Brueggen, D. Hoyer, H. Schmid,R. Jelinek, C. Gilon, A. Hoffman, H. Kessler, Improved Oral Bioavailability of Peptides via N-Methylation: Somatostatin Analogs, Angew.Chem Int. Ed. 2008, 47 (14), 2595-2599.

618. S. Knör, A. Khrenov, B. Laufer, A. Benhida, S. C. Grailly, R. Schwaab, J. Oldenburg, J.-M. R. Saint-Remy, E. L. Saenko, C. A. E. Hauser, H. Kessler, Efficient factor VIII affinity purification using a small synthetic ligand, J. Thromb. Haemostasis 2008, 6 (3), 470-477.

617. J. Chatterjee, D. Mierke, H. Kessler, Conformational Preference and Potential Templates of N-Methylated Cyclic Pentaalanine Peptides, Chemistry Eur. J. 2008, 14 (5), 1508-1517.

616. B. Luy, A. Frank, H. Kessler, “Conformational Analysis of Drugs by NMR Spectroscopy” in Molecular Drug Properties: Measurement and Prediction. Eds. R. Mannhold, H. Kubinyi, G. Folkers, Methods and Principles in Medicinal Chemistry, Vol. 37, Wiley, 2007, p.207-254.

615. J. Chatterjee, O. Ovadia, G. Zahn, L. Marinelli, A. Hoffman, C. Gilon, H. Kessler, Multiple N-Methylation by a Designed Approach Enhances Receptor Selectivity, J. Med. Chem. 2007, 50, 5878-5881.

614. S. Knör, S. Sato, T. Huber, A. Morgenstern, F. Bruchertseifer, M. Schmitt, H. Kessler, R.  Senekowitsch-Schmidtke, V. Magdolen, C. Seidl;  Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in α-emitter therapy of disseminated ovarian cancer, Eur. J. of Nuclear Med. Mol. Imag. 2008, 35, 53-64.

613. O. Lieleg, M. López-García, C. Semmrich, J. Auernheimer, H. Kessler and A. R. Bausch, Specific integrin labelling in living cells using functionalized nanocrystals, Small 2007, 3 (9), 1560-1565.

612. J. Klages, H. Kessler, S. J. Glaser, B. Luy; J-ONLY-TOCSY: Efficient Suppression of RDC-Induced Transfer in Homonuclear TOCSY Experiments Using JESTER-1-Derived Multiple Pulse Sequences, J. Magn. Res. 2007, 189, 217-227.

611. J. Furrer, M. John, H. Kessler; B. Luy; J-Spectroscopy in the Presence of Residual Dipolar Couplings: Determination of One-Bond Coupling Constants and Scalable Resolution, J. Biomol. NMR 2007, 37, 231-243.

610. D. Heckmann, H. Kessler, Design and Chemical Synthesis of Integrin Ligands, Methods in Enzymology 2007, 426, 463-503.

609. J. Blümmel, N. Perschmann, D. Aydin, J. Drinjakovic, T. Surrey, M. López-García , H. Kessler, J. P. Spatz, Protein Repellent Properties of Covalently Attached PEG Coatings on Nanostructured SiO2 Based Interfaces, Biomaterials 2007, 28, 4739-4747.

608. S. Knör, A. V. Khrenov, B. Laufer, E. L. Saenko, C. A. E. Hauser, H. Kessler, Development of a peptidomimetic ligand for efficient isolation and purification of factor VIII via affinity chromatography, J. Med. Chem. 2007, 50, 4329-4339.

607. S.V. Graeter, J. Huang, N. Perschmann, M. Lopez-Garcia, H. Kessler, J. Ding, J. P. Spatz, Mimicking Cellular Environments by Nanostructured Soft Interfaces, Nanoletters 2007, 7 (5), 1413-1418.

606. M. López-García, H, Kessler; Stimulation of Bone growth on implants by integrin ligands. Chapt. 8 in Handbook of Biomineralization, Eds. M. Epple, E. Baeuerlein, Wiley, Weinheim, 2007, pp.109-126.

605. S. Takahashi, M. Leiss, M. Moser, T. Ohashi, T. Kitao, D. Heckmann, A. Pfeifer, H. Kessler, J. Takagi, H. P. Erickson, R. Fässler, The RGD motif in fibronectin is essential for development but dispensable for fibril assembly, J. Cell Biol. 2007, 178 (1), 167-178.

604. S. Knör , A. Modlinger, T. Poethko, M. Schottelius, H.-J. Wester, H. Kessler, Synthesis of Novel 1,4,7,10-Tetraazacyclodecane-1,4,7,10-Tetraacetic Acid (DOTA) Derivatives for Chemoselective Attachment to Unprotected Polyfunctionalized Compounds, Chemistry Eur. J. 2007, 13(21), 6082-6090.

603. F. Manzenrieder, A. Frank, T. Huber, C. Dorner-Ciossek, H. Kessler; Synthesis and biological evaluation of phosphino dipeptide  isostere inhibitor of human β-secretase (BACE1) Bioorg. & Med. Chem. 2007, 15, 4136-4143.

602. E. Ada Cavalcanti-Adam, T. Volberg, A. Micoulet, H. Kessler, B. Geiger, J. P. Spatz; Cell Spreading and Focal Adhesion Dynamics are Regulated by Spacing of Integrin Ligands; Biophysical Journal 2007, 92, 2964-2974.

601. B. Luy, H. Kessler; Partial Alignment for Structure Determination of Organic Molecules; in “Handbook of Modern NMR-Methods”; Eds.: G. Webb, D. Craik;  Kluwer Academic Publishers, 2007, p.1261-1267.

600. D. Heckmann, A. Meyer, L. Marinelli, G. Zahn, R. Stragies, H. Kessler, Probing Integrin Selectivity: Rational Design of Highly Active and Selective Ligands for the a5b1 and avb3 Integrin Receptor. Angew. Chem. 2007, 119 (19), 3641-3644; Angew. Chem. Int. Ed. 2007, 46, 3571-3574.

599.
J. Furrer, M. John, H. Kessler; B. Luy; J-Spectroscopy in the Presence of Residual Dipolar Couplings: Determination of One-Bond Coupling Constants and Scalable Resolution, J. Biomol. NMR, 2006, 37 (3), 231-243.

598.
H. Kessler, J. Klages; Lead Search and Optimization: NMR in Drug Discovery“ (Vol. 3, p. 901-920) in „Comprehensive Medicinal Chemistry II“ (Eds.: D.J. Triggle and J.B. Taylor). Elsevier, Oxford 2006, ISBN 0080445136.

597.
M. J. Feige, F. Hagn, J. Eßer, H. Kessler, J. Buchner; Influence of the internal disulfide bridge on the folding pathway of the CL antibody domain; J.Mol. Biol. 2006, 365, 1232-1244.

596. 
J. Chatterjee, D. Mierke, H. Kessler, N-methylated Cyclic Penta-Alanine Peptides as Template Structures, J.Am.Chem.Soc. 2006, 128, 15164-15172.

595.
A. J. Beer, R. Haubner, M. Sarbia, M. Goebel, S. Luderschmidt, A. Ligia Grosu, O. Schnell, M. Niemeyer, H. Kessler, H.-J. Wester, W. A. Weber, M. Schwaiger; Positron Emission Tomography Using [18F]Galacto-RGD Identifies the Level of Integrin αvβ3 Expression in Man; Clinical Cancer Res. 2006, 12 (13), 3942-3949.

594. 
M. Heller, M. Sukopp, N. Tsomaia, M. John, D. F. Mierke, B. Reif, H. Kessler, The Conformation of Cyclo(-d-Pro-Ala4-): a Model for dl4 Cyclic Pentapeptides; J.Am.Chem.Soc. 2006, 128, 13806-13814.

593.
M. G. Friedel, J. C. Pieck, J. Klages, C. Dauth, H. Kessler, T. Carell; Synthesis and Stereochemical Assignment of DNA Spore Photoproduct Analogues; Chem. Eur.J. 2006, 12, 6081-6094.

592.
L. Römer, C. Klein, A. Dehner, H. Kessler, J. Buchner, p53 – a Natural Cancer Killer: Structural Insights and Therapeutic Concepts; Angew.Chem. Int. Ed. 2006, 45 (39), 6440-6460.

591.
A. Meyer, J. Auernheimer, A. Modlinger, H. Kessler; Targeting RGD Recognizing Integrins: Drug Development, Biomaterial Research, Tumor Imaging and Targeting; Curr. Pharmaceutical Design 2006, 12 (22), 2723 - 2747.

590.
S. Knoer, D. Heckmann, H. Kessler; Efficient enantioselective synthesis of condensed and aromatic ring-substituted tyrosine derivative; J.Org.Chem. 2006, 71 (15), 5625-5630.

589.
T. Weide, A. Modlinger, H. Kessler; Spatial Screening for the Identification of the Bioactive Conformation of Integrin Ligands; Topics in Curr. Chemistry 2007, 272, 1-50.

588.
M. V. Deshmukh, M. John, M. Coles, J. Peters, W. Baumeister, H. Kessler; Inter-domain orientation and motions in VAT-N explored by RDCs and 15N backbone relaxation; Magn. Res. Chem. 2006, 44, S89-S100.

587.
D. Lössner, H. Kessler, G. Thumshirn, C. Dahmen, M..Tanaka, W. Knoll, E.-K. Sinner, U. Reuning; Monitoring of the Binding of Small Mono- and Oligomeric Integrin Ligands to Membrane-Embedded Integrins by Surface Plasmon-Enhanced Fluorescence Spectroscopy; Analytical Chemistry 2006, 78 (13), 4524-4533.

586.
U. Magdolen, J- Auernheimer, C. Dahmen, J. Schauwecker, H. Gollwitzer, J. Tübel, R. Gradinger, H. Kessler, M. Schmitt, P. Diehl; Growth promoting in vitro effect of synthetic cyclic RGD-peptides on human osteoblast-like cells attached to cancellous bond; Internat. J. Molecular Medicine 2006, 17, 1017-1021.

585.
E. Biron, J. Chatterjee, H. Kessler; Solid-Phase Synthesis of Azole-Based Peptides and Peptidomimetics; Org. Lett. 2006, 8 (11), 2417-2420.

584.  
M. John, M. Wendeler, M. Heller, K. Sandhoff, H. Kessler; Characterization of Human Saposins by NMR Spectroscopy; Biochemistry 2006, 45, 5206-5216.

583.
J. Klages, M. Coles, H. Kessler; NMR-Based Screening: A Powerful Tool in Fragment-Based Drug Discovery; in “Exploiting Chemical Diversity for Drug Discovery” (Eds.: P. A. Bartlett, M. Entzeroth); RSC Publishing, Cambridge, 2006, Chapter 12; p. 263-290 and Mol.BioSyst. 2006, 2, 318-332.

582.
M. Haupt, M. Bramkamp, M. Coles, H. Kessler, K. Altendorf; The Prokaryotic Kdp-ATPase: Recent Insights in Structure and Function of KdpB; J. Mol.Microbiol. Biotechnol. 2006, 10, 120-131.

581.
M. Haupt, M. Bramkamp, M. Heller, M. Coles, G. Deckers-Hebestreit, B. Herkenhoff-Hesselmann, K. Altendorf, H. Kessler; The Holo-form of the Nucleotide Binding Domain of the KdpFABC Complex from  E. coli Reveals a New Binding Mode; J. Biol. Chem. 2006, 281(14), 9641-9649.

580.
E.A. Cavalcanti-Adam, A. Micoulet, J. Blümmel, J. Auernheimer, H. Kessler, J.P.Spatz; Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly; Eur. J. Cell Biol. 2006, 85 (3-4), 219-224.

579.
N. Walter, C. Selhuber, H. Kessler, J.P. Spatz; Cellular Unbinding Forces of Initial Adhesion processes on Nanopatterned Surfaces Probed with Magnetic Tweezers: Nano Letters 2006, 6 (3), 398-402.

578.
J. Auernheimer, R. Haubner, M. Schottelius, H.-J. Wester, H. Kessler; Radio-analytical determination of the coating efficiency of cyclic RGD-peptides; Helv Chim Acta 2006, 89, 833-840.

577.
K. Richter, S. Moser, F. Hagn, R. Friedrich, O. Hainzl, M. Heller, S. Schlee, H. Kessler, J. Reinstein, J. Buchner; Intrinsic Inhibition of the Hsp90 ATPase activity; J. Biol. Chem.2006, 281, 11301-11311.

576.
E. Biron, J. Chatterjee, H. Kessler; Optimized Selective N-Methylation of Peptides on Solid Support; J. Peptide Sci. 2006, 12, 213-219.

575.
Y. Tomita, N. Marchenko, S. Erster, A. Nemajerova, A. Dehner, C. Klein, H. Pan, H. Kessler, P. Pancoska, U. M. Moll; WT p53 but not tumor-derived mutants bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization; J. Biol. Chem. 2006, online

574.
S. Cesana, J. Auernheimer, R. Jordan, H. Kessler, O. Nuyken; First Poly(2- oxazoline)s with Pendant Amino Groups; Macromol. Chem. Phys. 2006, 207, 183-192

573.
J. Auernheimer, H. Kessler; Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium; Bioorg. Med. Chem. Lett. 2006, 16, 271-273

572.
T. Weide, L. Arve, H. Prinz, H. Waldmann, H. Kessler; 3-Substituted Indolizine-1-carbonitrile Derivatives as Phosphatase Inhibitors; Bioorg. Med.Chem. Lett. 2006, 16, 59-63

571.
H.-J. Wester, H. Kessler; Molecular Targeting with Peptides or Peptide-Polymer-Conjugates: just a question of size?; J. Nucl. Med. 2005, 46, 1940 -1945.

570.
J. Auernheimer, C. Dahmen, U. Hersel, A. Bausch, H. Kessler; Photo Switched Cell Adhesion on Surfaces with RGD Peptides; J. Amer. Chem. Soc. 2005, 127, 16107-16110.

569.
J. Auernheimer, C. Dahmen, M. Kantlehner, A. Enderle, D. Zukowski, S. L. Goodman, H. Kessler; Titanium Implant Materials with Improved Biocompatibility via Coating with Cyclic RGD-Peptides via Phosphonates; ChemBioChem 2005, 6, 2034-2040.

568.
J. Klages, C. Neubauer, M. Coles, H. Kessler, B. Luy; Structure Refinement of Cyclosporin A  in Chloroform by Using RDCs Measured in a Stretched PDMS-Gel; ChemBioChem 2005, 6, 1672-1678.

567.
A. Dehner, H. Kessler; Diffusion NMR Spectroscopy: Folding and Aggregation of Domains in p53; ChemBioChem 2005, 6, 1550-1565.

566.
H. Schwalbe, H. U. Stilz, H. Kessler; NMR Spectroscopy of Biomacromolecules in Drug Discovery and Beyond; ChemBioChem 2005, 6, 1475-1478.

565.
A. Dehner, C. Klein, S. Hansen, L. Müller, J. Buchner, M. Schwaiger, H. Kessler; Cooperative Binding of p53 to DNA: Regulation by Protein-Protein Interactions through a Double Salt Bridge; Angew. Chem. 2005, 117, 5381-5386; Angew. Chem. Int. Ed. 2005, 44, 5247-5251.

564.
T. Arndt, U. Arndt, U. Reuning, H. Kessler; Integrins in Angiogenesis: Implications for Tumor Therapy. – In: Cancer Therapy. Molecular Targets in Tumor-Host Interactions. Ed.: G. F. Weber; Horizon Bioscience, Norfolk, U.K. 2005, 93-141.

563.
L. Marinelli, A. Meyer, D. Heckmann, A. Lavecchia, E. Novellino, H. Kessler; Ligand Binding Analysis for Human α5β1 Integrin: Strategies for Designing New α5β1 Integrin Antagonists; J. Med. Chem. 2005, 48, 4204-4207.

562.
E. Biron, H. Kessler; Convenient Synthesis of N-Methylamino Acids Compatible with Fmoc Solid-Phase Peptide Synthesis; J. Org. Chem. 2005, 70, 5183-5189.

561.
B. Luy, K. Kobzar, S. Knör, J. Furrer, D. Heckmann, H. Kessler; Orientational Properties of Stretched Polystyrene Gels in Organic Solvents and the Suppression of Their Residual 1H NMR Signals; J. Am. Chem. Soc. 2005, 127, 6459-6465.

560.
K. Kobzar, H. Kessler, B. Luy; Stretched Gelatin Gels as Chiral Alignment Media for the Discrimination of Enantiomers by NMR Spectroscopy; Angew. Chem. 2005, 117, 3205-3207; Angew. Chem. Int. Ed. 2005, 44, 3145-3147.

559.
R. Haubner, W. A. Weber, A. J. Beer, E. Vabuliene, D. Reim, M. Sarbia, K.-F. Becker, M. Goebel, R. Hein, H.-J. Wester, H. Kessler, M. Schwaiger; Noninvasive Visualization of the Activated αvβ3 Integrin in Cancer Patients by Positron Emission Tomography and [18F]Galacto-RGD; PLoS Medicine 2005, 2, 244-252.

558.
M. Sukopp, R. Schwab, L. Marinelli, E. Biron, M. Heller, E. Várkondi, A. Pap, E. Novellino, G. Kéri, H. Kessler; Structure-Activity Relationship Studies Optimizing the Antiproliferative Activity of Novel Cyclic Somatostatin Analogues Containing a Restrained Cyclic β-Amino Acid; J. Med. Chem. 2005, 48, 2916-2926.

557.
M. V. Deshmukh, G. Voll, A. Kühlewein, H. Mäcke, J. Schmitt, H. Kessler, G. Gemmecker; NMR Studies Reveal Structural Differences between the Gallium and Yttrium Complexes of DOTA-D-Phe1-Tyr3-octreotide; J. Med. Chem. 2005, 48, 1506-1514.

556.
E. Lieb, M. Hacker, J. Tessmar, L. A. Kunz-Schughart, J. Fiedler, C. Dahmen, U. Hersel, H. Kessler, M. B. Schulz, A. Göpferich; Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with cyclic RGD peptides; Biomaterials 2005, 26, 2333-2341.

555.
V. Beck, H. Herold, A. Benge, B. Luber, P. Hutzler, H. Tschesche, H. Kessler, M. Schmitt, H.-G. Geppert, U. Reuning; ADAM15 decreases integrin αvβ3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion; Int. J. Biochem. & Cell Biol. 2005, 37, 590-603.

554.
J. C. Freudenberger, S. Knör, K. Kobzar, D. Heckmann, T. Paululat, H. Kessler, B. Luy; Stretched Poly(vinyl acetate) Gels as NMR Alignment Media for the Measurement of Residual Dipolar Couplings in Polar Organic Solvents; Angew. Chem. 2005, 117, 427-430; Angew. Chem. Int. Ed. 2005, 44, 423-426.

553.
T. Poethko, M. Schottelius, G. Thumshirn, M. Herz, R. Haubner, G. Henriksen, H. Kessler, M. Schwaiger, H.-J. Wester; Chemoselective pre-conjugate radiohalogenation of unprotected mono- and multimeric peptides via oxime formation; Radiochimica Acta 2004, 92, 317-327.

552.
M. Schottelius, T. Poethko, M. Herz, J.-C. Reubi, H. Kessler, M. Schwaiger, H.-J. Wester; First 18F-Labeled Tracer Suitable for Routine Clinical Imaging of sst Receptor-Expressing Tumors Using Positron Emission Tomography; Clinical Cancer Res. 2004, 10, 3593-3606.

551.
C. Dahmen, J. Auernheimer, A. Meyer, A. Enderle, S. L. Goodman, H. Kessler; Improving Implant Materials by Coating with Nonpeptidic, Highly Specific Integrin Ligands; Angew. Chem. 2004, 116, 6818-6821; Angew. Chem. Int. Ed. 2004, 43, 6649-6652.

550. 
J. C. Freudenberger, P. Spiteller, R. Bauer, H. Kessler, B. Luy; Stretched Poly(dimethylsiloxane) Gels as NMR Alignment Media for Apolar and Weakly Polar Organic Solvents: In Ideal Tool for Measuring RDCs at Low Molecular Concentrations; J. Am. Chem. Soc. 2004, 126, 14690-14691.

549.
M. Haupt, M. Bramkamp, M. Coles, K. Altendorf, H. Kessler; Inter-domain Motions of the N-domain of the KdpFABC Complex, a P-type ATPase, are not Driven by ATP-induced Conformational Changes; J. Mol. Biol. 2004, 342, 1547-1558.

548.
A. Kühlewein, G. Voll, B. Hernandez Alvarez, H. Kessler, G. Fischer, J.-U. Rahfeld, G. Gemmecker; Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases; Protein Sci. 2004, 13, 2378-2387.

547.
L. Marinelli, K.-E. Gottschalk, A. Meyer, E. Novellino , H. Kessler; Human Integrin αvβ5: Homology Modeling and Ligand Binding; J. Med. Chem. 2004, 47, 4166-4177.

546.
M. Haupt, M. Coles, V. Truffault, M. Bramkamp, K. Altendorf, H. Kessler; Letter to the Editor: 1H. 13C and 15N resonance assignment of the nucleotide binding domain of KdpB from Escherichia coli; J. Biomol. NMR 2004, 29, 437-438.

545.
S. Pallu, R. Bareille, M. Dard, H. Kessler, A. Jonczyk, M. Vernizeau, J. Amédée-Vilamitjana; A cyclo peptide activates signaling events and promotes growth and the production of the bone matrix; Peptides 2003, 24, 1349-1357.

544.
K.-E. Gottschalk, H. Kessler; A Computational Model of Transmembrane Integrin Clustering; Structure 2004, 12, 1109-1116.

543.
K.-E. Gottschalk, M. Soskine, S. Schuldiner , H. Kessler; A Structural Model of EmrE, a Multi-Drug Transporter from Escherichia coli; Biophys. J. 2004, 86, 3335-3348.

542.
T. Poethko, M. Schottelius, G. Thumshirn, U. Hersel, M. Herz, G. Henriksen, H. Kessler, M. Schwaiger, H.-J. Wester; Two-Step Methodology for High-Yield Routine Radiohalogenation of Peptides: 18F-Labeled RGD and Octreotide Analogs; J. Nucl. Med. 2004, 45, 892-902.

541.
C. Riemer, T. Bayer, H. Schmitt, H. Kessler; 3-Azido-aspartic acid derivatives – orthogonally protected precursors for the stereoselective incorporation of 2,3-diaminosuccinic acid into peptide structures; J. Peptide Res. 2004, 63, 196-199.

540.
M. Arnold, E. A. Cavalcanti-Adam, R. Glass, J. Blümmel, W. Eck, M. Kantlehner, H. Kessler, J. P. Spatz; Activation of Integrin Function by Nanopatterned Adhesive Interfaces; ChemPhysChem 2004, 5, 383-388.

539.
F. Kramer, M. V. Deshmukh, H. Kessler, S. J. Glaser; Residual Dipolar Coupling Constants: An Elementary Derivation of Key Equations; Concepts Magn. Reson. 2004, 21A, 10-21.

538. 
M. John, M. Heller, M. Coles, G. Bosch, W. Baumeister , H. Kessler; Letter to the Editor: 1H, 15N and 13C resonance assignments of α-ADT and β-ADT; J. Biomol. NMR 2004, 29, 209-210.

537.
R. Haubner, F. Bruchertseifer, M. Bock, H. Kessler, M. Schwaiger, H.-J. Wester; Synthesis and biological evaluation of a 99mTc-labelled cyclic RGD peptide for imaging the αvβ3 expression; Nuklearmedizin 2004, 43, 26-32.

536. 
M. Wendeler, J. Hoernschemeyer, M. John, N. Werth, M. Schoeniger, T. Lemm, R. Hartmann, H. Kessler, K. Sandhoff; Expression of the GM2-activator protein in the methylotrophic yeast Pichia pastoris, purification, isotopic labeling, and biophysical characterization; Protein Expr. Purif. 2004, 34, 147-157.

535.
D. D. Boyd, H. Wang, H. Avila, N. U. Parikh, H. Kessler, V. Magdolen, G. E. Gallick; Combination of an Src Kinase Inhibitor with a Novel Pharmacological Antagonist of the Urokinase Receptor Diminishes in Vitro Colon Cancer Invasiveness; Clinical Cancer Res. 2004, 10, 1545-1555.

534.
B. Luy, K. Kobzar, H. Kessler; An Easy and Scalable Method for the Partial Alignment of Organic Molecules for Measuring Residual Dipolar Couplings; Angew. Chem. 2004, 116, 1112-1115; Angew. Chem. Int. Ed. 2004, 43, 1092-1094.

533.
M. Heller, M. John, M. Coles, G. Bosch, W. Baumeister, H. Kessler; NMR Studies on the Substrate-binding Domains of the Thermosome: Structural Plasticity in the Protrusion Region; J. Mol. Biol. 2004, 336, 717-729

532.
R. Haubner, B. Kuhnast, C. Mang, W. A. Weber, H. Kessler, H.-J. Wester, M. Schwaiger; [18F]Galacto-RGD: Synthesis, Radiolabeling, Metabolic Stability, and Radiation Dose Estimates; Bioconjugate Chem. 2004, 15 61-69

531. 
K.-E. Gottschalk, H. Kessler; Evidence for hetero-association of transmembrane helices of integrins; FEBS Lett. 2004, 557, 253-258

530.
E. Locardi, J. Boer, A. Modlinger, A. Schuster, B. Holzmann, H. Kessler; Synthesis and Structure-Activity Relationship of Mannose-Based Peptidomimetics Selectively Blocking Integrin α4β7 Binding to Mucosal Addressin Cell Adhesion Molecule-1; J. Med. Chem. 2003, 46, 5752-5762.

529.
E. Mann, H. Kessler; New Oxazole-Based Peptidomimetics: Useful Building Blocks for the Synthesis of Orthogonally Protected Macrocyclic Scaffolds; Org. Lett. 2003, 5, 4567-4570.

528.
L. Marinelli, A. Lavecchia, K.-E. Gottschalk, E. Novellino, H. Kessler; Docking Studies on avb3 Integrin Ligands: Pharmacophore Refinement and Implications for Drug Design; J. Med. Chem. 2003, 46, 4393-4404.

527.
R. Dawson, L. Müller, A. Dehner, C. Klein, H. Kessler, J. Buchner; The N-terminal Domain of p53 is Natively Unfolded; J. Mol. Biol. 2003, 332, 1131-1141.

526.
R. M. van Well, L. Marinelli, C. Altona, K. Erkelens, G. Siegal, M. van Raaij, A. L. Llamas-Saiz, H. Kessler, E. Novellino, A. Lavecchia, J. M. van Boom, M. Overhand; Conformational Analysis of Furanoid e-Sugar Amino Acid Containing Cyclic Peptides by NMR Spectroscopy, Molecular Dynamics Simulation, and X-ray Crystallography: Evidence for a Novel Turn Structure; J. Am. Chem. Soc. 2003, 125, 10822-10829.

525.
A. Dehner, J. Furrer, K. Richter, I. Schuster, J. Buchner, H. Kessler; NMR Chemical Shift Perturbation Study of the N-Terminal Domain of Hsp90 upon Binding of ADP, AMP-PNP, Geldanamycin, and Radicicol; ChemBioChem 2003, 4, 870-877.

524.
M. Coles, M. Heller, H. Kessler ; NMR-based screening technologies; Drug Discovery Today 2003, 8, 803-810.

523.
U. Hersel, C. Dahmen, H. Kessler; RGD modified polymers: biomaterials for stimulated cell adhesion and beyond; Biomaterials 2003, 24, 4385-4415.

522.
B. Dittrich, T. Koritsnzky, M. Grosche, W. Scherer, R. Flaig, A. Wagner, H. G. Krane, H. Kessler, C. Riemer, A. M. M. Scheurs, P. Luger; Reproducability and transferability of topological properties; experimental charge density of the hexapeptide cyclo-(D,L-Pro)2-(L-Ala)4 monohydrate; Acta Cryst. 2002, B58, 721-727.

521.
U. Reuning, S. Sperl, C. Kopitz, H. Kessler, A. Krüger, M. Schmitt, V. Magdolen; Urokinase-type Plasminogen Activator (uPA) and ist Receptor (uPAR): Development of Antagonists of uPA/uPAR Interaction and their Effects In Vitro and In Vivo; Current Pharmaceutical Design 2003, 9, 1529-1543.

520.
J. Furrer, A. Enthart, A. Kühlewein, A. Dehner, C. Klein, S. Hansen, M. Schwaiger, H. Kessler, G. Gemmecker; Letter to the Editor: Backbone 1H, 13C and 15N resonance assignments for the 25.8 kDa DNA binding domain of the human p63 protein; J. Biomol. NMR 2003, 26, 377-378.

519.
S. Hapke, H. Kessler, B. Luber, A. Benge, P. Hutzler, H. Höfler, M. Schmitt, U. Reuning; Ovarian Cancer Cell Proliferation and Motility Is Induced by Engagement of Integrin avb3/Vitronectin Interaction; Biol. Chem. 2003, 384, 1073-1083.

518.
R. M. van Well, L. Marinelli, K. Erkelens, G. A. van der Marel, A. Lavecchia, H. S. Overkleeft, J. H. van Boom, H. Kessler, M. Overhand; Synthesis and Structural Analysis of Cyclic Oligomers Consisting of Furanoid and Pyranoid e-Sugar Amino Acids; Eur. J. Org. Chem. 2003, 2303-2313.

517.
G. Thumshirn, U. Hersel, S. L. Goodman, H. Kessler; Multimeric Cyclic RGD Peptides as Potential Tools for Tumor Targeting: Solid-Phase Peptide Synthesis and Chemoselective Oxime Ligation; Chem. Eur. J. 2003, 9, 2717-2725.

516.
D. Weber, C. Berger, P. Eickelmann, J. Antel, H. Kessler; Design of Selective Peptidomimetic Agonists for the Human Orphan Receptor BRS-3; J. Med. Chem. 2003, 46, 1918-1930.

515.
E. Guthaus, N. Schmiedeberg, M. Bürgle, V. Magdolen, H. Kessler, M. Schmitt; The Urokinase Receptor (uPAR, CD87) as a Target for Tumor Therapy: uPA-Silica Particles (SP-uPA) as a New Tool for Assessing Synthetic Peptides to Interfere with uPA/uPA-Receptor Interaction; Recent Results Cancer Res. 2003, 162, 3-14.

514.
R. Mühlberger, R. Robelek, W. Eisenreich, C. Ettenhuber, E. K. Sinner, H. Kessler, A. Bacher, G. Richter; RNA DNA Discrimination by the Antitermination Protein NusB; J. Mol. Biol. 2003, 327, 973-983.

513.
C. Dahmen, A. Janotta, D. Dimova-Malinovska, S. Marx, B. Jeschke, B. Nies, H. Kessler, M. Stutzmann; Surface functionalization of amorphous silicon and silicon suboxides for biological applications; Thin Solid Films 2003, 427, 201-207.

512.
H. Kessler, M. Heller, G. Gemmecker, T. Diercks, E. Planker, M. Coles; NMR in Medicinal Chemistry. - In: Small Molecule - Protein Interactions (Ernst Schering Research Foundation, Workshop 42) Eds.: H. Waldmann, M. Koppitz; Springer Verlag Berlin, Heidelberg 2003, 59-85.

511.
V. Marchi-Artzner, B. Lorz, C. Gosse, L. Jullien, R. Merkel, H. Kessler, E. Sackmann; Adhesion of Arg-Gly-Asp (RGD) Peptide Vesicles onto an Integrin Surface: Visualization of the Segregation of RGD Ligands into the Adhesion Plaques by Fluorescence; Langmuir 2003, 19, 835-841.

510.
E. Gräfin von Roedern, M. A. Born, M. Stöckle, H. Kessler; Synthesis of Peptides with Sugar Amino Acids. - In: Houben-Weyl: Methods of Organic Chemistry. Vol. E 22c: Synthesis of Peptides and Peptidomimetics; Eds.: M. Goodman, A. Felix, L. Moroder, C. Toniolo; Thieme Verlag, Stuttgart, New York 2003, 807-821.

509.
J. Gante, H. Kessler, C. Gibson; Synthesis of Azapeptides. - In: Houben-Weyl: Methods of Organic Chemistry. Vol. E 22c: Synthesis of Peptides and Peptidomimetics; Eds.: M. Goodman, A. Felix, L. Moroder, C. Toniolo; Thieme Verlag, Stuttgart, New York 2003, 311-323.

508.
C. Gilon, M. A. Dechantsreiter, F. Burkhart, A. Friedler, H. Kessler; Synthesis of N-Alkylated Peptides. In: Houben-Weyl: Methods of Organic Chemistry. Vol. E 22c: Synthesis of Peptides and Peptidomimetics; Eds.: M. Goodman, A. Felix, L. Moroder, C. Toniolo; Thieme Verlag, Stuttgart, New York 2003, 215-271.

507.
E. Locardi, H. Kessler; High Resolution NMR Spectroscopy. - In: Houben-Weyl: Methods of Organic Chemistry. Vol. E 22b: Synthesis of Peptides and Peptidomimetics; Eds.: M. Goodman, A. Felix, L. Moroder, C. Toniolo; Thieme Verlag, Stuttgart, New York 2003, 670-679.

506.
C. Gilon, C. Mang, E. Lohof, A. Friedler, H. Kessler; Synthesis of Cyclic Peptides. - In: Houben-Weyl: Methods of Organic Chemistry. Vol. E 22b: Synthesis of Peptides and Peptidomimetics; Eds.: M. Goodman, A. Felix, L. Moroder, C. Toniolo; Thieme Verlag, Stuttgart, New York 2003, 461-542.

505.
M. Sukopp, L. Marinelli, M.. Heller, T. Brandl, R. W. Hoffmann, H.. Kessler; Evaluation of structural features of a designed beta-turn mimic by incorporation into a cyclic RGD peptide. - In: Peptides 2002 (Proc. 27th European Peptide Symp., Aug. 31 - Sept. 6, 2002, Sorrento, Italy) Eds.: E. Benedetti, C. Pedone; Edizioni Ziino, Napoli, Italy, 2002, 898-899.

504.
C. Dahmen, U. Hersel, M. Kantlehner, J. Auernheimer, D. Finsinger, J. Meyer, P. Schaffner, A. Jonczyk, B. Diefenbach, B. Nies, H. Kessler; Biofunctionalization of different surface types via αvβ3 integrin selelctive RGD peptides. - In: Peptides 2002 (Proc. 27th European Peptide Symp., Aug. 31 - Sept. 6, 2002, Sorrento, Italy) Eds.: E. Benedetti, C. Pedone; Edizioni Ziino, Napoli, Italy, 2002, 456-457.

503.
G. Thumshirn, G. A. G. Sulyok, D. Weber, S. L.. Goodman, M. Wiesner, H. Kessler; Synthesis and biological evaluation of highly active nonpeptidic
αvβ3 integrin antagonists. - In: Peptides 2002 (Proc. 27th European Peptide Symp., Aug. 31 - Sept. 6, 2002, Sorrento, Italy) Eds.: E. Benedetti, C. Pedone; Edizioni Ziino, Napoli, Italy, 2002, 298-299.

502.
T. Arndt, D. Gottschling, J. Boer, A. Schuster, B. Holzmann, H. Kessler; Peptide derived non-peptidic
αvβ7-integrin antagonists. - In: Peptides 2002 (Proc. 27th European Peptide Symp., Aug. 31 - Sept. 6, 2002, Sorrento, Italy) Eds.: E. Benedetti, C. Pedone; Edizioni Ziino, Napoli, Italy, 2002, 22-23.

501. M. Sukopp, L. Marinelli, M. Heller, T. Brandl, S. L. Goodman, R. W. Hoffmann, H. Kessler; Designed Beta-Turn Mimic Based on the Allylic-Strain Concept: Evaluation of Structural and Biological Features by Incorporation into a Cyclic RGD Peptide (Cyclo(-L-arginylglycyl-L-(-aspartyl-)); Helv. Chim. Acta 2002, 85, 4442-4452.

500.
Z. Szabo, M. Tönnis, H. Kessler, M. Feldbrügge; Structure-function analysis of lipopeptide pheromones from the plant pathogen Ustilago maydis; Mol. Genet. Genomics 2002, 268, 362-370.

499.
N. Schmiedeberg, M. Schmitt, C. Rolz, V. Truffault, M. Sukopp, M. Burgle, O. G. Wilhelm, W. Schmalix, V. Magdolen, H. Kessler; Synthesis, Solution Structure, and Biological Evaluation of Urokinase Type Plasminogen Activator (uPA)-Derived Receptor Binding Domain Mimetics; J. Med. Chem. 2002, 45, 4984-4994.

498.
M. Bürgle, S. Sperl, J. Stürzebecher, A. Krüger, W. Schmalix, H. Kessler, L. Moroder, V. Magdolen, O. G. Wilhelm, M. Schmitt; The urokinase-type plasminogen activator (uPA) system: a new target for tumor therapy. In: Proteinase and Peptidase Inhibition: Recent potential targets for drug Development; Eds.: H. J. Smith, C. Simons; Taylor & Francis; London, New York 2002, 231-248.

497.
K.-E. Gottschalk, H. Kessler; The Structures of Integrins and Integrin-Ligand Complexes: Implications for Drug Design and Signal Transduction; Angew. Chem. 2002, 114, 3919-3927; Angew. Chem. Int. Ed. 2002, 41, 3767-3774.

496.
S. Sato, C. Kopitz, W. A. Schmalix, B. Muehlenweg, H. Kessler, M. Schmitt, A. Krüger, V. Magdolen; High-affinity urokinase-derived cyclic peptides inhibiting urokinase/urokinase receptor-interaction: effects on tumor growth and spread; FEBS Lett. 2002, 528, 212-216.

494.
D. Gottschling, J. Boer, A. Schuster, B. Holzmann, H. Kessler; Combina-torial and Rational Strategies To Develop Nonpeptidic a4b7-Integrin Antagonists from Cyclic Peptides; Angew. Chem. 2002, 114, 3133-3137; Angew. Chem. Int. Ed. 2002, 41, 3007-3011.

495.
S. A. W. Gruner, V. Truffault, G. Voll, E. Locardi, M. Stöckle, H. Kessler; Design, Synthesis, and NMR Structure of Linear and Cyclic Oligomers Containing Novel Furanoid Sugar Amino Acids; Chem. Eur. J. 2002, 8, 4365-4376.

493.
D. Weber, C. Berger, T. Heinrich, P. Eickelmann, J. Antel, H. Kessler; Systematic optimization of a lead-structure identities for a selective short peptide agonist for the human orphan receptor BRS-3; J. Peptide Sci. 2002, 8, 461-475.

492.
M. Stöckle, G. Voll, R. Günther, E. Lohof, E. Locardi, S. Gruner, H. Kessler; Synthesis and NMR Studies of Cyclopeptides Containing a Sugar Amino Acid; Org. Lett. 2002, 4, 2501-2504.

491.
B. Jeschke, J. Meyer, A. Jonczyk, H. Kessler, P. Adamietz, N. M. Meenen, M. Kantlehner, C. Goepfert, B. Nies; RGD-peptides for tissue engineering of articular cartilage; Biomaterials 2002, 23, 3455-3463.

490.
K. Prechtel, A. R. Bausch, V. Marchi-Artzner, M. Kantlehner, H. Kessler, R. Merkel; Dynamic Force Spectroscopy to Probe Adhesion Strength of Living Cells; Phys. Rev. Lett. 2002, 89, 028101-1 – 028101-4.

489.
K. E. Gottschalk, P. D. Adams, A. T. Brunger, H. Kessler; Transmembrane signal transduction of the aIIbb3 integrin; Protein Science 2002, 11, 1800-1812.

488.
D. Gottschling, J. Boer, L. Marinelli, G. Voll, M. Haupt, A. Schuster, B. Holzmann, H. Kessler; Synthesis and NMR Structure of Peptidomimetic a4b7-Integrin Antagonists; ChemBioChem 2002, 3, 575-578.

487.
K. E. Gottschalk, R. Günther, H. Kessler; A Three-State Mechanism of Integrin Activation and Signal Transduction for Integrin αvβ3; ChemBioChem 2002, 3, 470-473.

486.
H. Lüttgen, R. Robelek, R. Mühlberger, T. Diercks, S. C. Schuster, P. Köhler, H. Kessler, A. Bacher, G. Richter; Transcriptional Regulation by Antitermination. Interaction of RNA with NusB Protein and NusB/NusE Protein Complex of Escherichia coli; J. Mol. Biol. 2002, 316, 875-885.

485.
E. Guthaus, M. Bürgle, N. Schmiedeberg, S. Hocke, A. Eickler, M. D. Kramer, C. G. J. F. Sweep, V. Magdolen, H. Kessler, M. Schmitt; uPA-Silica-Particles (SP-uPA): A Novel Analytical System to Investigate uPA-uPAR Interaction and to Test Synthetic uPAR Antagonists as Potential Cancer Therapeutics; Biol. Chem. 2002, 383, 207-216.

484.
S. L. Goodman, G. Hölzemann, G. A. G. Sulyok, H. Kessler; Nanomolar Small Molecule Inhibitors for avb6, avb5, and avb3 Integrins; J. Med. Chem. 2002, 45, 1045-1051.

483.
S. A. W. Gruner, E. Locardi, E. Lohof, H. Kessler; Carbohydrate-Based Mimetics in Drug Design: Sugar Amino Acids and Carbohydrate Scaffolds; Chem. Rev. 2002, 102, 491-514.

482.
  N. Schmiedeberg, H. Kessler; Reversible Backbone Protection Enables Combinatorial Solid-Phase Ring-Closing Metathesis Reaction (RCM) in Peptides; Org. Lett. 2002, 4, 59-62.

481.
S.A.W. Gruner, H. Kessler, G. Kéri, A. Venetianer; Active Somatostatin Analogues Containig Sugar Amino Acids – in: Peptides: The Wave of the Future (Proc. 2nd Intern. and 17th American Peptide Symp., June 9-14, 2001, San Diego, California, USA) Eds.: M. Lebl, R. A. Houghten; American Peptide Society, San Diego, 2001, 664-665.

480.
H. Kessler, J. Boer, D. Gottschling, N. Schmiedeberg, C. Rölz, V. Truffault, B. Holzmann, A. Schuster, M. Bürgle, O. Wilhelm, V. Magdolen, M. Schmitt; Peptidic Inhibitors for Protein-Protein Interactions at Cell Surfaces – in: Peptides: The Wave of the Future (Proc. 2nd Intern. and 17th American Peptide Symp., June 9-14, 2001, San Diego, California, USA) Eds.: M. Lebl, R. A. Houghten; American Peptide Society, San Diego, 2001, 647-649.

479.
J. Boer, E. Locardi, A. Schuster, B. Holzmann, H. Kessler; ß-D-Mannose Based Peptidomimetics in the Design of α4β1 and avb7 Antagonists – in: Peptides: The Wave of the Future (Proc. 2nd Intern. and 17th American Peptide Symp., June 9-14, 2001, SanDiego, California, USA) Eds.: M. Lebl, R. A. Houghten; American Peptide Society, San Diego, 2001, 612-613.

478.
C. Klein, E. Planker, T. Diercks, H. Kessler, K.-P. Künkele, K. Lang, S. Hansen, M. Schwaiger; NMR Spectroscopy Reveals the Solution Dimerization Interface of p53 Core Domains Bound to Their Consensus DNA; J. Biol. Chem. 2001, 276, 49020-49027.

477.
S. A. W. Gruner, G. Kéri, R. Schwab, A. Venetianer, H. Kessler; Sugar Amino Acid Containing Somatostatin Analogues that Induce Apoptosis in Both Drug-Sensitive and Multidrug-Resistant Tumor Cells; Org. Lett. 2001, 3, 3723-3725.

476.
D. Gottschling, J. Boer, A. Schuster, B. Holzmann, H. Kessler; Cellular Solid-Phase Binding Assay and Mass Spectrometry for Screening of a4b7 Integrin Antagonists; Bioorg. Med. Chem. Lett. 2001, 11, 2997-3000.

475.
M. Heller, H. Kessler; NMR spectroscopy in drug design (Hungarian-German-Italian-Polish Joint Meeting on Medicinal Chemistry; September 2-6, 2001, Budapest, Hungary) Pure Appl. Chem. 2001, 73, 1429-1436.

474.
R. Haubner, H. J. Wester, W. A. Weber, W. Linke, C. Bodenstein, H. Kessler, M. Schwaiger; Improved Pharmacokinetics of [18F]RGD-Peptides by Serine-Conjugation (14. Intern. Symp. on Radiopharmaceutical Chemistry, Interlaken, Schweiz, 10.-15.06.2001) J. Labelled Cpd. Radiopharm. 2001, 44 (Suppl. 1) S157-S159.

473.
R. Haubner, W. A. Weber, H. J. Wester, S. I. Ziegler, E. Vabuliene, E. K. Chorianopoulos, H. Kessler, M. Schwaiger; Non-Invasive Determination of the αvβ3 Integrin Expresssion Using [18F]Galacto-RGD and PET (14. Intern. Symp. on Radiopharmaceutical Chemistry, Interlaken, Schweiz, 10.-15.06.2001) J. Labelled Cpd. Radiopharm. 2001, 44 (Suppl. 1) S96-S98.

472.
J. Boer, D. Gottschling, A. Schuster, B. Holzmann, H. Kessler; Design, Synthesis, and Biological Evaluation of α4β1 Integrin Antagonists Based on β-D-Mannose as Rigid Scaffold; Angew. Chem. 2001, 113, 3988-3991; Angew. Chem. Int. Ed. 2001, 40, 3870-3873.

471.
E. Locardi, M. Stöckle, S. Gruner, H. Kessler; Cyclic Homooligomers from Sugar Amino Acids: Synthesis, Conformational Analysis, and Significance; J. Am. Chem. Soc. 2001, 123, 8189-8196.

470.
V. Magdolen, M. Bürgle, N. Arroyo de Prada, N. Schmiedeberg, C. Riemer, F. Schroeck, J. Kellermann, K. Degitz, O. G. Wilhelm, M. Schmitt, H. Kessler; Cyclo19,31[D-Cys19]-uPA19-31 Is a Potent Competitive Antagonist of the Interaction of Urokinase-Type Plasminogen Activator with Its Receptor (CD87); Biol. Chem. 2001, 382, 1197-1205.

469.
J. Boer, D. Gottschling, A. Schuster, M. Semmrich, B. Holzmann, H. Kessler; Design and Synthesis of Potent and Selective α4β7 Integrin Antagonists; J. Med. Chem. 2001, 44, 2586-2592.

468.
S. Hapke, H. Kessler, N. Arroyo de Prada, A. Benge, M. Schmitt, E. Lengyel, U. Reuning; Integrin
αvβ3/Vitronectin Interaction Affects Expression of the Urokinase System in Human Ovarian Cancer Cells; J. Biol. Chem. 2001, 276, 26340-26348.

467.
A. Dehner, E. Planker, G. Gemmecker, Q. B. Broxterman, W. Bisson, F. Formaggio, M. Crisma, C. Toniolo, H. Kessler; Solution Structure, Dimerization, and Dynamics of a Lipophilic α/310-Helical, Cα–Methylated Peptide. Implications for Folding Membrane Proteins; J. Am. Chem. Soc. 2001, 123, 6678-6686.

466.
V. Truffault, M. Coles, T. Diercks, K. Abelmann, S. Eberhardt, H. Lüttgen, A. Bacher, H. Kessler; The Solution Structure of the N-terminal Domain of Riboflavin Synthase; J. Mol. Biol. 2001, 309, 949-960.

465.
G.A.G. Sulyok, C. Gibson, S.L. Goodman, G. Hölzemann, M. Wiesner, H. Kessler; Solid-Phase Synthesis of a Nonpeptidic RGD Mimetic Library: New Selective
αvβ3 Integrin Antagonists; J. Med. Chem. 2001, 44, 1938-1950.

464.
T. Diercks, M. Coles, H. Kessler; Applications of NMR in drug discovery; Curr. Opin. Chem. Biol. 2001, 5, 285-291.

463.
T. Bayer, C. Riemer, H. Kessler; A New Strategy for the Synthesis of Cyclopeptides Containing Diaminoglutaric Acid; J. Peptide Sci. 2001, 7, 250-261.

462.
R. Haubner, H.-J. Wester, W. A. Weber, C. Mang, S. I. Ziegler, S. L. Goodman, R. Senekowitsch-Schmidtke, H. Kessler, M. Schwaiger; Noninvasive Imaging of
αvβ3 Integrin Expression Using 18F-labeled RGD-containing Glycopeptide and Positron Emission Tomography; Cancer Res. 2001, 61, 1781-1785.

461.
S. Gruner, H. Kessler; Linear and Cyclic Oligomers of Two New Furanoid Sugar Amino Acids. – In: Peptides 2000 (Proc. 26th European Peptide Symposium, Sept. 10-15, 2000, Montpellier, France) Eds.: J. Martinez, J.-A. Fehrentz; Editions EDK, Paris, France 2001, 313-314.

460.
R. Haubner, H.-J. Wester, F. Burkhart, R. Senekowitsch-Schmidtke, W. Weber, S. L. Goodman, H. Kessler, M. Schwaiger; Glycosylated RGD-Containing Peptides: Tracer for Tumor Targeting and Angiogenesis Imaging with Improved Biokinetics; J. Nucl. Med. 2001, 42, 326-336.

459.
V. Marchi-Artzner, B. Lorz, U. Hellerer, M. Kantlehner, H. Kessler, E. Sackmann; Selective Adhesion of Endothelial Cells to Artificial Membranes with a Synthetic RGD-Lipopeptide; Chem. Eur. J. 2001, 7, 1095-1101.

458.
C. Gibson, G.A.G. Sulyok, D. Hahn, S.L. Goodman, G. Hölzemann, H. Kessler; Bibliotheken niedermolekularer
αvβ3-Integrin-antagonisten: On-Bead-Screening und massenspektrometrische Identifizierung ohne Codierung; Angew. Chem. 2001, 113, 169-173; Angew. Chem. Int. Ed. 2001, 40, 165-169.

457.
N. Schmiedeberg, M. Bürgle, O. Wilhelm, F. Lottspeich, H. Graeff, M. Schmitt, V. Magdolen, H. Kessler; Design and biological activity of new high-affinity ligands for the urokinase-type plasminogen activator receptor (CD87). - In: Peptides for the New Millennium(Proc. 16th American Peptide Symposium, June 26-July 1, 1999, Minneapolis, Minnesota, USA) Eds.: G. B. Fields, J. P. Tam, G. Barany; Kluwer Academic Publishers, Dordrecht, The Netherlands 2000, 543-545.

456.
H. Kessler, M. Kantlehner, C. Gibson, R. Haubner, D. Finsinger, M. Dechantsreiter, E. Planker, J. Wermuth, J. S. Schmitt, J. Meyer, P. Schaffner, G. Hölzemann, M. Wiesner, S. L. Goodman, D. Hahn, A. Jonczyk, H. J. Wester, M. Schwaiger; Recent progress in the field of αv-integrin antagonists. - In: Peptides for the New Millennium (Proc. 16th American Peptide Symposium, June 26-July 1, 1999, Minneapolis, Minnesota, USA) Eds.: G. B. Fields, J. P. Tam, G. Barany; Kluwer Academic Publishers, Dordrecht, The Netherlands 2000, 235-237.

455.
H. Kessler; Hoffnung auf neues Krebsmedikament; Spektrum der Wissenschaft (Nov.) 2000, 48-53.

454.
C. Gibson, G. Sulyok, J. S. Schmitt, M. A. Dechantsreiter, R. Haubner, G. Hölzemann, S. L. Goodman, H. Kessler; From Proteins to Drugs: The RGD Story. - In: The 8th Akabori Conference (Proc. 8th Akabori Conference, Japanese-German Symposium on Peptide Science, April 26-29, 2000, Nagoya, Japan) Ed.: T. Shioiri; Akabori Conference Association, Nagoya, Japan, 2000, 1-5.

453.
B. Hu, D. Finsinger, K. Peter, Z. Guttenberg, M. Bärmann, H. Kessler, A. Escherich, L. Moroder, J. Böhm, W. Baumeister, Sen-fang Sui, E. Sackmann; Intervesicle Cross-Linking with Integrin aIIbb3 and Cyclic-RGD-Lipopeptide. A Model of Cell-Adhesion Processes; Biochemistry 2000, 39, 12284-12294.

452.
C. Glaubitz, A. Gröger, K. Gottschalk, P. Spooner, A. Watts, S. Schuldiner, H. Kessler; 31P-CP-MAS NMR studies on TPP+ bound to the ion-coupled multidrug transport protein EmrE; FEBS Lett. 2000, 480, 127-131.

451.
M. Kantlehner, P. Schaffner, D. Finsinger, J. Meyer, A. Jonczyk, B. Diefenbach, B. Nies, G. Hölzemann, S. L. Goodman, H. Kessler; Surface Coating with Cyclic RGD Peptides Stimulates Osteoblast Adhesion and Proliferation as well as Bone Formation; ChemBioChem 2000, 1, 107-114.

450.
E. Lohof, E. Planker, C. Mang, F. Burkhart, M. A. Dechantsreiter, R. Haubner, H.-J. Wester, M. Schwaiger, G. Hölzemann, S. L. Goodman, H. Kessler; Kohlenhydratderivate im Wirkstoffdesign am Beispiel von cyclischen αv-selektiven RGD-Peptiden; Angew. Chem. 2000, 112, 2868-2871; Angew. Chem. Int. Ed. 2000, 39, 2761-2764.

449.
M. Schmitt, O. G. Wilhelm, U. Reuning, A. Krüger, N. Harbeck, E. Lengyel, H. Graeff, B. Gänsbacher, H. Kessler, M. Bürgle, J. Stürzebecher, S. Sperl, V. Magdolen; The urokinase plasminogen activator system as a novel target for tumor therapy; Fibrinol. Proteol. 2000, 14, 114-132.

448.
B. Muehlenweg, E. Guthaus, N. Arroyo de Prada, M. Schmitt, N. Schmiedeberg, M. Kotzsch, S. Creutzburg, M. D. Kramer, H. Kessler, O. G. Wilhelm, V. Magdolen; Epitope Mapping of Monoclonal Antibodies Directed to PAI-1 Using PAI-1/PAI-2 Chimera and PAI-1-Derived Synthetic Peptides; Thromb. Res. 2000, 98, 73-81.

447.
C. Gibson, H. Kessler; 2-Fluoropyrimidine as an efficient reagent in solid-phase synthesis of N-aryl- and N-alkyl-N-pyrimidin-2-ylamines; Tetrahedron Lett. 2000, 41, 1725-1728.

446.
T. Zhang, X.-A. Mao, M. Baur, H. Kessler; NOESY around the critical point w tc = 1.12. Precise determination of proton-proton distances and reorientation correlation times with two-field NOESY; Mol. Phys. 2000, 98, 201-210.



   
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