Publications - 1990 - 1999

445.
M. Huenges, H. Kessler; Structural Chemistry Using NMR Spectroscopy, Peptides. - In: Encyclopedia of Spectroscopy and Spectrometry. Eds.: J.C. Lindon, G.E. Trauter, J.L. Holmes; Academic Press Ltd., London, England 1999, 2246-2260.

444.
P. Schaffner, J. Meyer, M. Dard, R. Wenz, B. Nies, S. Verrier, H. Kessler, M. Kantlehner; Induced tissue integration of bone implants by coating with bone selective RGD-peptides in vitro and in vivo studies; Journal of Materials Science: Materials in Medicine 1999, 10, 837-839.

443.
X.-A. Mao, T. Zhang, M. Baur, H. Kessler; Two-field-NOESY for precise determination of proton-proton distances and correlation times; J. Chem. Phys. 1999, 111, 8253-8254.

442.
T. Diercks, M. Coles, H. Kessler; An efficient strategy for assignment of cross-peaks in 3D heteronuclear NOESY experiments; J. Biomol. NMR 1999, 15, 177-180.

441.
M. Koppitz, B. Mathä, H. Kessler; Structure Inverstigation of Amphiphilic Cyclopeptides in Isotropic and Anisotropic Environments - A Model Study Simulating Peptide-Membrane Interactions; J. Peptide Sci. 1999, 5, 507-518.

440.
H. Kessler, R. Konat, M. Kurz, C. Gilon; Conformational Design of Bioactive Peptides. - In: Future Aspects in Peptide Chemistry (Collection Symposium Series Vol. 1) Eds.: W. Voelter, G. Fischer; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague 1999, 86-94.

439.
M. Coles, T. Diercks, J. Liermann, A. Gröger, B. Rockel, W. Baumeister, K.K. Koretke, A. Lupas, J. Peters, H. Kessler; The solution structure of VAT-N reveals a 'missing link' in the evolution of complex enzymes from a simple ß(ßß element; Current Biology 1999, 9, 1158-1168.

438.
C. Gibson, S. L. Goodman, D. Hahn, G. Hölzemann, H. Kessler; Novel Solid-Phase Synthesis of Azapeptides and Azapeptoids via Fmoc-Strategy and Its Application in the Synthesis of RGD-Mimetics; J. Org. Chem. 1999, 64, 7388-7394.

437.
E. Lohof, F. Burkhart, M. A. Born, E. Planker, H. Kessler; Sugar Amino Acids and Carbohydrates as Scaffolds and Peptidomimetics. - in: Advances in Amino Acid Mimetics and Peptidomimetics (Vol. 2) Ed.: A. Abell; JAI Press Inc., Stanford, Connecticut 1999, 263-292.

436.
D. M. Korzhnev, V. Yu. Orekhov, A. S. Arseniev, R. Gratias, H. Kessler; Mechanism of the Unfolding of Transmembrane (-Helical Segment (1-36)-Bacteriorhodopsin Studied by Molecular Dynamics Simulations; J. Phys. Chem. B 1999, 103, 7036-7043.

435.
V. Yu. Orekhov, D. M. Korzhnev. T. Diercks, H. Kessler, A. S. Arseniev; ¹H-¹⁵N NMR dynamic study of an isolated (-helical peptide (1-36)-bacteriorhodopsin reveals the equilibrium helix-coil transitions; J. Biomol. NMR 1999, 14, 345-356.

434.
C. Riemer, T. Bayer, H. Kessler; Chiral Pool Derived Synthesis of 2,3-Diaminosuccinic Acid as a Peptidomimetic Building Block. - In: Peptides 1998 (Proc. 25^th European Peptide Symposium, Aug. 30 - Sep. 4, 1998, Budapest, Ungarn) Eds.: S. Bajusz, F. Hudecz; Akadémiai Kiadó; Budapest, Ungarn 1999, 690-691.

433.
T. Bayer, C. Riemer, H. Kessler; Synthesis of Orthogonally Protected 2,4-Diaminoglutaric Acid Containing Peptides by Solid Phase Ugi Four Component Condensation. - In: Peptides 1998 (Proc. 25^th European Peptide Symposium, Aug. 30 - Sep. 4, 1998, Budapest, Ungarn) Eds.: S. Bajusz, F. Hudecz; Akadémiai Kiadó; Budapest, Ungarn 1999, 652-653.

432.
H. Kessler, M. Bürgle, C. Riemer, V. Magdolen, O. Wilhelm, M. Schmitt; Inhibition of uPA/uPAR-Interaction by Cyclic uPA-Derived Peptides. - In: Peptides 1998 (Proc. 25^th European Peptide Symposium, Aug. 30 - Sep. 4, 1998, Budapest, Ungarn) Eds.: S. Bajusz, F. Hudecz; Akadémiai Kiadó; Budapest, Ungarn 1999, 72-73.

431.
H. Kessler, F. Burkhart, M. Koppitz, E. Lohof; Non-natural peptide modifications using sugars and lipophilic side chains. - In: Peptide Science - Present and Future (Proc. 1^st International Peptide Symposium, Nov. 30 - Dec. 5, 1997, Kyoto, Japan) Ed.: Y. Shimonishi; Kluwer Academic Publishers; Dordrecht, The Netherlands 1999, 587-594.

430.
G. Hölzemann, S. L. Goodman, C. Rölz, H. Kessler; Cyclic RGD peptides with a novel mimetic. - In: Peptide Science - Present and Future (Proc. 1^st International Peptide Symposium, Nov. 30 - Dec. 5, 1997, Kyoto, Japan) Ed.: Y. Shimonishi; Kluwer Academic Publishers, Dordrecht, The Netherlands 1999, 430-431.

429.
O. Mechnich, G. Hessler, M. Bernd, B. Kutscher, H. Kessler; Synthesis and conformational analysis of axinastatin 5 and derivatives. - In: Peptides - Frontiers of Peptide Science (Proc. 15^th American Peptide Symposium, June 14-19, 1997, Nashville, Tennessee, USA) Eds.: J. P. Tam, P. T. P. Kaumaya; Kluwer Academic Publishers, Dordrecht, The Netherlands 1999, 465-466.

428.
F. Burkhart, G. Hessler, H. Kessler; Synthesis and conformational analysis of C- and N-glycopeptides. - In: Peptides - Frontiers of Peptide Science (Proc. 15^th American Peptide Symposium, June 14-19, 1997, Nashville, Tennessee, USA) Eds.: J. P. Tam, P. T. P. Kaumaya; Kluwer Academic Publishers, Dordrecht, The Netherlands 1999, 449-450.

427.
G. Hölzemann, S.L. Goodman, W. Schmitt, R. Haubner, H. Kessler; From Peptides to Non-Peptides. First Applications with Cyclic RGD Peptides. - In: Proc. 7^th Akabori Conference (Japanese-German Symposium on Peptide Chemistry, April 27-30, 1998, Heidelberg, Germany) Ed.: H. Kunz; University Mainz 1998, 62-66.

426.
H. Kessler, M. Schwaiger, M. Bürgle, A. Gröger, M. Coles, M. Lebendiker, H. Yerushalmi, S. Schuldiner; The Multi-Drug-Resistance Protein EmrE - high resolution NMR investigations and secondary structure. - In: Proc. 7^th Akabori Conference (Japanese-German Symposium on Peptide Chemistry, April 27-30, 1998, Heidelberg, Germany) Ed.: H. Kunz; University Mainz 1998, 30-35.

425.
M. Coles, T. Diercks, B. Muehlenweg, S. Bartsch, V. Zölzer, H. Tschesche, H. Kessler; The Solution Structure and Dynamics of Human Neutrophil Gelatinase-associated Lipocalin; J. Mol. Biol. 1999, 289, 139-157.

424.
J. Balbach, S. Seip, H. Kessler, M. Scharf, N. Kashani-Poor, J. W. Engels; Structure and Dynamic Properties of the Single Disulfide-Deficient (-Amylase Inhibitor [C45A/C73A]Tendamistat: An NMR Study; Proteins: Structure, Function, and Genetics 1998, 33, 285-294.

423.
J. S. Schmitt, S. L. Goodman, A. Jonczyk, H. Kessler; Synthesis of cyclic RGD-tetra-peptoids and optimization of the submonomer solid phase coupling protocol. - In: Peptides - Frontiers of Peptide Science (Proc. 15^th American Peptide Symposium, June 14-19, 1997, Nashville, Tennessee, USA) Eds.: J. P. Tam, P. T. P. Kaumaya; Kluwer Academic Publishers, Dordrecht, The Netherlands 1999, 206-207.

422.
O. Mechnich, G. Hessler, M. Bernd, R. Voegeli, B. Kutscher, H. Kessler; Synthesis and Conformational Analysis of Axinastatin 4. - In: Peptides 1996 (Proc. 24^th European Peptide Symposium, September 8-13, 1996, Edinburgh, Scotland) Eds.: R. Ramage, E. Epton; Mayflower Scientific Ltd., England 1998, 629-630.

421.
J. Lutz, R. Romano-Götsch, C. Escrieut, D. Fourmy, B. Mathä, G. Müller, H. Kessler, L. Moroder; Mapping of the Ligand Binding Site of CCK-B/Gastrin Receptor with Lipo-Gastrin Peptides. - In: Peptides 1996 (Proc. 24^th European Peptide Symposium, September 8-13, 1996, Edinburgh, Scotland) Eds.: R. Ramage, R. Epton; Mayflower Scientific Ltd., England 1998, 603-604.

420.
H. Kessler, M. Koppitz, B. Mathä; Peptides at Hydrophilic-Lipophilic Interphase. - In: Peptides 1996 (Proc. 24^th European Peptide Symposium, September 8-13, 1996, Edinburgh, Scotland) Eds.: R. Ramage, R. Epton; Mayflower Scientific Ltd., England 1998, 535-536.

419.
D. Finsinger, R.K. Konat, W. Schmitt, H. Kessler; Regioselective Thionylation of Tertiary Amide Bonds in Cyclic Tetrapeptides - A Conformational Approach. - In: Peptides 1996 (Proc. 24^th European Peptide Symposium, September 8-13, 1996, Edinburgh, Scotland) Eds.: R. Ramage, R. Epton; Mayflower Scientific Ltd., England 1998, 381-382.

418.
M.A. Dechantsreiter, B. Mathä, A. Jonczyk, S.L. Goodman, H. Kessler; Synthesis and Conformational Studies of N-methylated Cyclic RGD-peptides. - In: Peptides 1996 (Proc. 24^th European Peptide Symposium, September 8-13, 1996, Edinburgh, Scotland) Eds.: R. Ramage, R. Epton; Mayflower Scientific Ltd., England 1998, 329-330.

417.
D. Besse, S. Pegoraro, T. Diercks, H. Kessler, L. Moroder; Selenocysteine as Useful Device for Selective Disulfide Pairings in Multiple Cysteine Peptides. - In: Peptides 1996 (Proc. 24^th European Peptide Symposium, September 8-13, 1996, Edinburgh, Scotland) Eds.: R. Ramage, R. Epton; Mayflower Scientific Ltd., England 1998, 253-254.

416.
M. Kantlehner, D. Finsinger, J. Meyer, P. Schaffner, A. Jonczyk, B. Diefenbach, B. Nies, H. Kessler; Selektive RGD-vermittelte Adhäsion von Osteoblasten an Implantat-Oberflächen; Angew. Chem. 1999, 111, 587-590; Angew. Chem. Int. Ed. 1999, 38, 560-562.

415.
H. Kessler, G. Gemmecker; NMR-Based Modeling of Protein-Protein Complexes and Interaction of Peptides and Proteins with Anisotropic Solvents. - In: NMR in Supramolecular Chemistry (Proc. of the NATO Advanced Workshop on Applications of NMR to the Study of Structure and Dynamics of Supramolecular Complexes, Sitges, Spain, May 5-9, 1998) Ed.: M. Pons; Kluwer Academic Publishers, Dordrecht, The Netherlands (NATO ASI Ser. C, Vol. 526) 1999, 255-266.

414.
F. Burkhart, M. Hoffmann, H. Kessler; C-Glycosides: A Stereoselective Synthesis of a- and ß-C-Galactosides with Glycosyl Dianions; Tetrahedron Lett. 1998, 39, 7699-7702.

413.
M.S. Goligorsky, H. Kessler, V.I. Romanov.; Molecular mimicry of integrin ligation: therapeutic potential of arginine-glycine-aspartic acid (RGD) peptides; Nephrol. Dial. Transplant. 1998, 13, 254-263.

412.
V. Magdolen, S. Albrecht, M. Kotzsch, C. Haller, M. Bürgle, U. Jacob, M. Großer, H. Kessler, H. Graeff, M. Müller, M. Schmitt, T. Luther; Immunological and Functional Analyses of the Extracellular Domain of Human Tissue Factor; Biol. Chem. 1998, 379, 157-165.

411.
M. Huenges, C. Rölz, R. Gschwind, R. Peteranderl, F. Berglechner, G. Richter, A. Bacher, H. Kessler, G. Gemmecker; Solution structure of the antitermination protein NusB of Escherichia coli: a novel all-helical fold for an RNA-binding protein; EMBO J. 1998, 17, 4092-4100.

410.
K. Fischer, V. Lutz, O. Wilhelm, M. Schmitt, H. Graeff, P. Heiss, T. Nishiguchi, N. Harbeck, H. Kessler, T. Luther, V. Magdolen, U. Reuning; Urokinase induces proliferation of human ovarian cancer cells: characterization of structural elements required for growth factor function; FEBS Letters 1998, 438, 101-105.

409.
M. Bachelin, G. Hessler, G. Kurz, J.G. Hacia, P.B. Dervan, H. Kessler; Structure of a stereoregular phosphorothioate DNA/RNA duplex; Nat. Struct. Biol. 1998, 5, 271-276.

408.
S. F. Martin, G. O. Dorsey, T. Gane, M. C. Hillier, H. Kessler, M. Baur, B. Mathä, J. W. Erickson, T. N. Bhat, S. Munshi, S. V. Gulnik, I. A. Topol; Cyclopropane-Derived Peptidomimetics. Design, Synthesis, Evaluation, and Structure of Novel HIV-1 Protease Inhibitors; J. Med. Chem. 1998, 41, 1581-1597.

407.
R. M. Gschwind, G. Gemmecker, H. Kessler; New Multi-quantum Version of the HBHA(CBCACO)NH Experiment with Enhanced Sensitivity for Partially Deuterated Samples; J. Magn. Reson. 1999, 137, 285-288.

406.
R. Haubner, H.-J. Wester, R. Senekowitsch-Schmidtke, B. Diefenbach, H. Kessler, G. Stöcklin, M. Schwaiger; Radiolabeled avß3 Integrin Antagonists: A New Class of Tracers for Tumor Targeting; J. Nucl. Med. 1999, 40, 1061-1071.

405.
M.A. Dechantsreiter, E. Planker, B. Mathä, E. Lohof, G. Hölzemann, A. Jonczyk, S.L. Goodman, H. Kessler; N-Methylated Cyclic RGD Peptides as Highly Active and Selective avß3 Integrin Antagonists; J. Med. Chem. 1999, 42, 3033-3040.

404.
J. Schmitt, M. Bernd, B. Kutscher, H. Kessler; Synthesis of Dolastatin 15 Mimetic Peptoids; Bioorg. & Med. Chem. Lett. 1998, 8, 385-388.

403.
F. Burkhart, H. Kessler; C-Glycosides: A Stereoselective Synthesis of a-C-Galactosamines with a Glycosyl Dianion; Tetrahedron Lett. 1998, 39, 255-256.

402.
M. A. Dechantsreiter, F. Burkhart, H. Kessler; A Stereoselective Synthesis of a C-Glycosylated Peptoid Building Block; Tetrahedron Lett. 1998, 39, 253-254.

401.
C. Gilon, M. Huenges, B. Mathä, G. Gellerman, V. Hornik, M. Afargan, O. Amitay, O. Ziv, E. Feller, A. Gamliel, D. Shohat, M. Wanger, O. Arad, H. Kessler; A Backbone-Cyclic, Receptor 5-Selective Somatostatin Analogue: Synthesis, Bioactivity, and Nuclear Magnetic Resonance Conformational Analysis; J. Med. Chem. 1998, 41, 919-929.

400.
R. M. Gschwind, G. Gemmecker, H. Kessler; A spin labeled and highly resolved ed-H(CCO)NH-TOCSY experiment for the facilitated assignment of proton side chains in partially deuterated samples; J. Biomol. NMR 1998, 11, 191-198.

399.
M. Baur, G. Gemmecker, H. Kessler; 13C-NOESY-HSQC with Split Carbon Evolution for Increased Resolution with Uniformly Labeled Proteins; J. Magn. Reson. 1998, 132, 191-196.

398.
M. Schwaiger, M. Lebendiker, H. Yerushalmi, M. Coles, A. Gröger, C. Schwarz, S. Schuldiner, H. Kessler; NMR investigation of the multidrug transporter EmrE, an integral membrane protein; Eur. J. Biochem. 1998, 254, 610-619.

397.
R. Gratias, R. Konat, H. Kessler, M. Crisma, G. Valle, A. Polese, F. Formaggio, C. Toniolo, Q.B. Broxterman, J. Kamphuis; First Step Towards the Quantitative Identification of Peptide 310-Helix Conformation with NMR Spectroscopy: NMR and X-Ray Diffraction. Structural Analysis of a Fully-Developed 310-Helical Peptide Standard; J. Am. Chem. Soc. 1998, 120, 4763-4770.

396.
R. Gratias, H. Kessler; Molecular Dynamics Study on Microheterogeneity and Preferential Solvation in Methanol/ Chloroform Mixtures; J. Phys. Chem. B 1998, 102, 2027-2031.

395.
M.S. Goligorsky, E. Noiri, H. Kessler, V. Romanov; Therapeutic potential of RGD peptides in acute renal injury; Kidney International 1997, 51, 1487-1492.

394.
M. Baur, H. Kessler; Novel Suppression of the Diagonal Signals in the NOESY Experiment; Magn. Reson. Chem. 1997, 35, 877-882.

393.
V. Romanov, E. Noiri, G. Czerwinski, D. Finsinger, H. Kessler, M.S. Goligorsky; Two novel probes reveal tubular and vascular Arg-Gly-Asp (RGD) binding sites in the ischemic rat kidney; Kidney International 1997, 52, 93-102.

392.
F. Berglechner, G. Richter, M. Fischer, A. Bacher, R.M. Gschwind, M. Huenges, G. Gemmecker, H. Kessler; Studies on the NusB protein of Escherichia coli. Expression and determination of secondary-structure elements by multinuclear NMR spectroscopy; Eur. J. Biochem. 1997, 248, 338-346.

391.
L. Goretzki, J. Bognacki, M. Koppitz, P. Rettenberger, V. Magdolen, S. Creutzburg, J. Hammelburger, U. H. Weidle, O. Wilhelm, H. Kessler, H. Graeff, M. Schmitt; Quantitative assessment of interaction of urokinase-type plasminogen activator and its receptor (CD87) by use of a solid-phase uPA-ligand binding assay; Fibrinolysis & Proteolysis 1997, 11, 11-19.

390.
O. Mechnich, G. Hessler, H. Kessler, M. Bernd, B. Kutscher; Cyclic Heptapeptides Axinastatin 2, 3, and 4: Conformational Analysis and Evaluation of the Biological Potential; Helv. Chim. Acta 1997, 80, 1338-1354.

389.
M. Bürgle, M. Koppitz, C. Riemer, H. Kessler, B. König, U.H. Weidle, J. Kellermann, F. Lottspeich, H. Graeff, M. Schmitt, L. Goretzki, U. Reuning, O. Wilhelm, V. Magdolen; Inhibition of the Interaction of Urokinase-Type Plasminogen Activator (uPA) with Its Receptor (uPAR) by Synthetic Peptides; Biol. Chem. 1997, 378, 231-237.

388.
T. Luther, V. Magdolen, S. Albrecht, M. Kasper, C. Riemer, H. Kessler, H. Graeff, M. Müller, M. Schmitt; Epitope-Mapped Monochloral Antibodies as Tools for Functional and Morphological Analyses of the Human Urokinase Receptor in Tumor Tissue; Amer. J. Pathol. 1997, 150, 1231-1244.

387.
T. Diercks, M. Schwaiger, H. Kessler; HSQC-based Methyl Group Selection via Gradients in Multidimensional NMR Spectroscopy of Proteins; J. Magn. Reson. 1998, 130, 335-340.

386.
M. Hoffmann, H. Kessler; Competition of Deprotonation and Tin-Lithium Exchange in the Generation of a Glycosyl Dianion; Tetrahedron Lett. 1997, 38, 1903-1906.

385.
O. Mechnich, H. Kessler; What are the structures of phakellistatin 2 and phakellistatin 4? Lett. Pept. Sci. 1997, 4, 21-28.

384.
F. Burkhart, M. Hoffmann, H. Kessler; Stereoselektive Synthese eines C-glycosidischen Analogons des N-Glucoasparagins; Angew. Chem. 1997, 109, 1240-1241; Angew. Chem. Int. Ed. Engl. 1997, 36, 1191-1192.

383.
R. Haubner, D. Finsinger, H. Kessler; Stereoisomere Peptid-Bibliotheken und Peptidmimetika zum Design von selektiven Inhibitoren des avß3-Integrins für eine neuartige Krebstherapie; Angew. Chem. 1997, 109, 1440-1456; Angew. Chem. Int. Ed. Engl. 1997, 36, 1374-1389.

382.
H. Kessler; Ein neuartiges Verfahren zur Wirkstoffsuche mit einem kombinatorisch-rationalen Ansatz; Angew. Chem. 1997, 109, 857-859; Angew. Chem. Int. Ed. Engl. 1997, 36, 829-831.

381.
M. Leutner, R.M. Gschwind, J. Liermann, C. Schwarz, G. Gemmecker, H. Kessler; Automated backbone assignment of labeled proteins using the threshold accepting algorithm; J. Biomol. NMR 1998, 11, 31-43.

380.
M. Koppitz, M. Huenges, R. Gratias, H. Kessler, S.L. Goodman, A. Jonczyk; Synthesis of Unnatural Lipophilic N-(9H-Fluoren-9-ylmethoxy)carbonyl-Substituted a-Amino Acids and Their Incorporation into Cyclic RGD-Peptides: A Structure-Activity Study; Helv. Chim. Acta 1997, 80, 1280-1300.

379.
M. Baur, H. Kessler; An Easy Way for Resolution Enhancement in Out-and-Back Triple-Resonance Experiments Applied to the HCACO Sequence; J. Magn. Reson. 1997, 126, 270-273.

378.
R. M. Gschwind, G. Gemmecker, M. Leutner, H. Kessler, R. Gutknecht, R. Lanz, K. Flükiger, B. Erni; Secondary structure of the IIB domain of the Escherichia coli mannose transporter, a new fold in the class of a/ß twisted open-sheet structures; FEBS Lett. 1997, 404, 45-50.

377.
G. Gemmecker, M. Eberstadt, A. Buhr, R. Lanz, S. Golic Grdadolnik, H. Kessler, B. Erni; Glucose Transporter of Escherichia coli: NMR Characterization of the Phosphocysteine Form of the IIBGlc Domain and Its Binding Interface with the IIAGlc Subunit; Biochemistry 1997, 36, 7408-7417.

376.
D. Besse, F. Siedler, T. Diercks, H. Kessler, L. Moroder; Das Redoxpotential von Selenocystin in konformativ nicht eingeschränkten cyclischen Peptiden; Angew. Chem. 1997, 109, 915-917; Angew. Chem. Int. Ed. Engl. 1997, 36, 883-885.

375.
R. Weinkauf, P. Schanen, A. Metsala, E. W. Schlag, M. Bürgle, H. Kessler; Highly Efficient Charge Transfer in Peptide Cations in the Gas Phase: Threshold Effects and Mechanism; J. Phys. Chem. 1996, 100, 18567-18585.

374.
J. Lutz, R. Romano-Götsch, C. Escrieut, D. Fourmy, B. Mathä, G. Müller, H. Kessler, L. Moroder; Mapping of Ligand Binding Sites of the Cholecystokinin-B/Gastrin Receptor with Lipo-Gastrin Peptides and Molecular Modeling; Biopolymers 1997, 41, 799-817.

373.
R.K. Konat, D.F. Mierke, H. Kessler; Conformational Homogeneity and Solvent Effects in Cyclic Peptides. - in: Peptides: Chemistry, Structure and Biology (Proc. of the 14th Am. Pept. Symp., June 18-23, 1995, Columbus, Ohio, USA) Eds.: P.T.P. Kaumaya, R.S. Hodges; Mayflower Scientific Ltd., England 1996, 839-840.

372.
E. Graf von Roedern, E. Lohof, M. Hoffmann, G. Hessler, H. Kessler; Sugar Amino Acids as Novel Peptidomimetics. - In: Peptides: Chemistry, Structure and Biology (Proc. of the 14th American Peptide Symp., June 18-23, 1995, Columbus, Ohio, USA) Eds.: P.T.P. Kaumaya, R.S. Hodges; Mayflower Scientific Ltd., England 1996, 682-684.

371.
R. Haubner, R. Gratias, S.L. Goodman, H. Kessler; RGD plus X: Structure/Activity Investigations on Cyclic RGD-peptides. - In: Peptides: Chemistry, Structure and Biology (Proc. of the 14th American Peptide Symp., June 18-23, 1995, Columbus, Ohio, USA) Eds.: P.T.P. Kaumaya, R.S. Hodges; Mayflower Scientific Ltd., England 1996, 205-206.

370.
M. Koppitz, R. Haeßner, T. Spellig, R. Kahmann, H. Kessler; Synthesis, Activities and Conformational Analysis of Pheromone Derivatives of Ustilago maydis. - In: Peptides: Chemistry, Structure and Biology (Proc. of the 14th American Peptide Symp., June 18-23, 1995, Columbus, Ohio, USA) Eds.: P.T.P. Kaumaya, R.S. Hodges; Mayflower Scientific Ltd., England 1996, 201-202.

369.
L. Käsbeck, H. Kessler; Convenient Syntheses of 2,3,4,6-Tetra- O-alkylated D-Glucose and D-Galactose; Liebigs Ann./Recueil 1997, 169-173.

368.
L. Käsbeck, H. Kessler; Synthesis of S-a-D-Glucosylated L- Cysteine - A Novel S-Glycosyl Amino Acid; Liebigs Ann./Recueil 1997, 165-167.

367.
S. Behrens, B. Mathä, G. Bitan, C. Gilon, H. Kessler; Structure-activity relationship of the ring portion in backbone-cyclic C-terminal hexapeptide analogs of substance P: NMR and molecular dynamics; Int. J. Peptide Protein Res. 1996, 48, 569-578.

366.
M. Hoffmann, F. Burkhart, G. Hessler, H. Kessler; C-Glycoside Analogues of N4-(2-Acetamido-2-deoxy-ß-D-glucopyranosyl)-L-asparagine: Synthesis and Conformational Analysis of a Cyclic C-Glycopeptide; Helv. Chim. Acta 1996, 79, 1519-1532.

365.
J. Wermuth, S.L. Goodman, A. Jonczyk, H. Kessler; Stereoisomerism and Biological Activity of the Selective and Superactive avß3 Integrin Inhibitor cyclo(-RGDfV-) and Its Retro-Inverso Peptide; J. Am. Chem. Soc. 1997, 119, 1328-1335.

364.
M. Kranz, H. Kessler; Novel Synthesis of a Phe-Gly E-Alkene Dipeptide Isostere; Tetrahedron Lett. 1996, 37, 5359- 5362.

363.
O. Mechnich, H. Kessler; Synthesis of Axinastatins 2-5; Tetrahedron Lett. 1996, 37, 5355-5358.

362.
H. Kessler, R.K. Konat, W. Schmitt; Conformational Analysis of Peptides: Application to Drug Design. - in: NMR in Drug Design (CRC Series in Analytical Biotechnology) Ed.: D.J. Craik; CRC Press, Inc., Boca Raton, New York, London, Tokyo; 1996, S. 215-244.

361.
H. Kessler, W. Guba, B. Mathä, M. Koppitz, R. Haeßner, J. Lutz, L. Moroder; Peptides at Hydrophilic-Lipophilic Interphases. - In: The Sixth Akabori Conference (Proc. 6th Akabori Conference, Japanese-German Symposium on Peptide Chemistry, April 17-20, 1996, Ohtsu, Japan) Ed.: Y. Shimonishi; Protein Research Foundation, Osaka, Japan 1996, 172-177.

360.
E. Graf von Roedern, E. Lohof, G. Hessler, M. Hoffmann, H. Kessler; Synthesis and Conformational Analysis of Linear and Cyclic Peptides Containing Sugar Amino Acids; J. Am. Chem. Soc. 1996, 118, 10156-10167.

359.
K. Michael, H. Kessler; MICHAEL-Type Additions in the Synthesis of a-O- and -S-2-Deoxyglycosides; Tetrahedron Lett. 1996, 37, 3453-3456.

358.
M. Eberstadt, S. Golic Grdadolnik, G. Gemmecker, H. Kessler, A. Buhr, B. Erni; Solution Structure of the IIB Domain of the Glucose Transporter of Escherichia coli; Biochemistry 1996, 35, 11286- 11292.

357.
R. Haubner, W. Schmitt, G. Hölzemann, S. L. Goodman, A. Jonczyk, H. Kessler; Cyclic RGD Peptides Containing ß-Turn Mimetics; J. Am. Chem. Soc. 1996, 118, 7881-7891.

356.
M. Koppitz, T. Spellig, R. Kahmann, H. Kessler; Lipoconjugates: structure- aktivity studies for pheromone analogues of Ustilago maydis with varied lipophilicity; Int. J. Peptide Protein Res. 1996, 48, 377-390.

355.
R. Haubner, R. Gratias, B. Diefenbach, S.L. Goodman, A. Jonczyk, H. Kessler; Structural and Functional Aspects of RGD-Containing Cyclic Pentapeptides as Highly Potent and Selective Integrin avß3 Antagonists; J. Am. Chem. Soc. 1996, 118, 7461-7472.

354.
W. Schmitt, G. Zanotti, T. Wieland, H. Kessler; Conformation of Different S- Deoxo-Xaa3-amaninamide-Analogues in DMSO Solution as Determined by NMR-Spectroscopy. Strong CD Effects Induced by ßI,ßII Conformational Change; J. Am. Chem. Soc. 1996, 118, 4380- 4387.

353.
G. Bitan, S. Behrens, B. Mathä, Y. Mashriki, M. Hanani, H. Kessler, C. Gilon; New backbone cyclic substance P analogs; Lett. Pept. Sci. 1995, 2, 121-124.

352.
V. Magdolen, P. Rettenberger, M. Koppitz, L. Goretzki, H. Kessler, U.H. Weidle, B. König, H. Graeff, M. Schmitt, O. Wilhelm; Systematic mutational analysis of the receptor-binding region of the human urokinase- type plasminogen activator; Eur. J. Biochem. 1996, 237, 743-751.

351.
E. Lioy, H. Kessler; Synthesis of a New Chiral Peptide Analogue of DNA Using Ornithine Subunits and Solid-Phase Peptide Synthesis Methodologies; Liebigs Ann. 1996, 201-204.

350.
H. Kessler, B. Diefenbach, D. Finsinger, A. Geyer, M. Gurrath, S. L. Goodman, G. Hölzemann, R. Haubner, A. Jonczyk, G. Müller, E. Graf von Roedern, J. Wermuth; Design of superactive and selective integrin receptor antagonists containing the RGD sequence; Lett. Pept. Sci. 1995, 2, 155-160.

349.
B. Kutscher, M. Bernd, T. Beckers, T. Klenner, E. E. Polymeropoulos, J. Engel, A. Kleemann, M. Bachelin, T. Diercks, H. Kessler; Synthetic Peptides as Ligands for the Characterization of the Human LHRH-Receptor. - in: The Sixth Akabori Conference (Proc. 6th Akabori Conference, Japanese-German Symposium on Peptide Chemistry, April 17-20, 1996, Ohtsu, Japan) Ed.: Y. Shimonishi; Protein Research Foundation, Osaka, Japan 1996, 127-132.

348.
K. Michael, V. Wittmann, W. König, J. Sandow, H. Kessler; S- and C- glycopeptide derivatives of an LH-RH agonist; Int. J. Peptide Protein Res. 1996, 48, 59-70.

347.
H. Kessler, R. Gratias, G. Hessler, M. Gurrath, G. Müller; Conformation of cyclic peptides. Principle concepts and the design of selectivity and superactivity in bioactive sequences by "spatial screening"; Pure & Appl. Chem. 1996, 68, 1201-1205.

346.
D. Besse, S. Pegoraro, T. Diercks, H. Kessler, L. Moroder; Controlled Disulfide Bridging in Multiple Cysteine-Containing Peptides with Built-In Selenocysteines. - in: The Sixth Akabori Conference (Proc. 6th Akabori Conference, Japanese-German Symposium on Peptide Chemistry, April 17- 20, 1996, Ohtsu, Japan) Ed.: Y. Shimonishi; Protein Research Foundation, Osaka, Japan 1996, 24-29.

345.
J. Wermuth, S. Goodman, H. Kessler; Conformational differences of cyclic RGD-peptides and their retro-inverso isomers: The effect on antiadhesive activities. - in: Peptides 1994 (Proc. of the 23rd European Peptide Symposium, Sept. 4-10, 1994, Braga, Portugal) Ed.: H.L.S. Maia, ESCOM, Leiden 1995, 648-649.

344.
R.K. Konat, S. Golic Grdadolnik, W. Schmitt, H. Kessler; Conformational studies on cyclic tetrapeptides: Hydrophobic cluster formation. - in: Peptides 1994 (Proc. of the 23rd European Peptide Symposium, Sept. 4-10, 1994, Braga, Portugal) Ed.: H.L.S. Maia, ESCOM, Leiden 1995, 521-522.

343.
O. Frey, M. Hoffmann, H. Kessler; Stereoselektive Synthese von Retro- Isomeren des N-Glucoasparagins; Angew. Chem. 1995, 107, 2194-2195; Angew. Chem. Int. Ed. Engl. 1995, 34, 2026-2028.

342.
G. Gemmecker, H. Kessler; Methodology and Applications of Heteronuclear and Multidimensional 13C NMR to the Elucidation of Molecular Structure and Dynamics in the Liquid State. - in: Carbon-13 NMR Spectroscopy of Biological Systems. Hrsg.: N. Beckmann, Academic Press, Inc. 1995, 7-64.

341.
H. Kessler, E. Graf von Roedern, E. Lohof, R. Haubner, A. Geyer, V. Wittmann; New Peptidomimetics and Conformational Consequences. - in: 5th Akabori Conference (Proc. of the 5th Akabori Conference, German-Japanese Symposium on Peptide Chemistry, Dresden, May 8-12, 1994) Hrsg.: E. Wünsch, Max-Planck-Gesellschaft, Germany 1994, 110-115.

340.
R.K. Konat, B. Mathä, J. Winkler, H. Kessler; Axinastatin 1 or Malaysiatin? Proof of Constitution and 3D Structure in Solution of a Cyclic Heptapeptide with Cytostatic Properties; Liebigs Ann. 1995, 765-774.

339.
H. Kessler, W. Schmitt; Peptides & Polypeptides. - in: Encyclopedia of Nuclear Magnetic Resonance. Vol. 6. Eds.: D. M. Grant, R. K. Harris; John Wiley & Sons, Ltd., Chichester, 1996, 3527-3537.

338.
H. Kessler; Dynamics by NMR. - in: Encyclopedia of Nuclear Magnetic Resonance. Vol. 1 (Historical Perspectives) Eds.: D. M. Grant, R. K. Harris; John Wiley & Sons, Ltd., Chichester 1996, 424-425.

337.
O. Frey, M. Hoffmann, V. Wittmann, H. Kessler, P. Uhlmann, A. Vasella; Preparation and Transmetallation of a Triphenylstannyl ß-D- Glucopyranoside: A Highly Stereoselective Route to ß-D-C-Glycosides via Glycosyl Dianions; Helv. Chim. Acta 1994, 77, 2060- 2069.

336.
H. Matter, H. Kessler; Structures, Dynamics and Biological Activities of 15 Cyclic Hexapeptide Analogs of the a-Amylase Inhibitor Tendamistat (HOE 467) in Solution; J. Am. Chem. Soc. 1995, 117, 3347- 3359.

335.
E. Noiri, J. Gailit, D. Sheth, H. Magazine, M. Gurrath, G. Müller, H. Kessler, M. S. Goligorsky; Cyclic RGD peptides ameliorate ischemic acute renal failure in rats; Kidney International 1994, 46, 1050-1058.

334.
H. Kessler, M. Eberstadt, W. Schmitt; Multidimensional NMR Spectroscopy of Proteins. in: NMR of Biological Macromolecules. Ed.: C. I. Stassinopoulou; NATO ASI Series, Vol. H 87; Springer-Verlag, Berlin 1994, S. 171-188.

333.
W. Jahnke, M. Baur, G. Gemmecker, H. Kessler; Improved Accuracy of NMR Structures by a Modified NOESY-HSQC Experiment; J. Magn. Reson. 1995, 106 B, 86-88.

332.
W. Jahnke, H. Kessler; Modifizierte Tripelresonanz-NMR- Experimente mit erhöhter Empfindlichkeit für schnell austauschende Protonen; Angew. Chem. 1995, 107, 536-538; Angew. Chem. Int. Ed. Engl. 1995, 34, 469-471.

331.
M. Eberstadt, W. Guba, H. Kessler, H. Kogler, D.F. Mierke; Conformation and Dynamics of Dimeric Ureido-Balhimycin; Biopolymers 1995, 36, 429-437.

330.
H. Matter, G. Gemmecker, H. Kessler; Influence of Serine in Position i on Conformation and Dynamics of Reverse Turns; Int. J. Peptide Protein Res. 1995, 45, 430-440.

329.
M. Eberstadt, G. Gemmecker, D.F. Mierke, H. Kessler; Skalare Kopplungen - ihre Analyse und ihre Verwendung zur Strukturaufklärung; Angew. Chem. 1995, 107, 1813-1838; Angew. Chem. Int. Ed. Engl. 1995, 34, 1671-1695.

328.
M. Hoffmann, H. Kessler; A Stereoselective Synthesis of 2-Acetamido-2- deoxy-C-glucosides: Glycosyl Dianions as Key Intermediates; Tetrahedron Lett. 1994, 35, 6067-6070.

327.
W. Jahnke, H. Kessler; Enhanced sensitivity of rapidly exchanging amide protons by improved phase cycling and the constructive use of radiation damping; J. Biomol. NMR 1994, 4, 735-740.

326.
J. Balbach, H. Kessler; 13C-Edited Double-Quantum Spectroscopy of Peptides and Proteins; J. Magn. Reson. 1994, 105B, 83-87.

325.
G. Müller, M. Gurrath, H. Kessler; Pharmacophore refinement of gpIIb/IIIa antagonists based on comparative studies of antiadhesive cyclic and acyclic RGD peptides; J. Comp-Aided Mol. Design 1994, 8, 709-730.

324.
H. Kessler, K. Michael, M. Kottenhahn; TMS Triflate-Promoted O- Glycosylation of Amino Acids and Peptides by L-Acosaminal and L- Ristosaminal; Liebigs Ann. Chem. 1994, 811-816.

323.
M. Pfaff, K. Tangemann, B. Müller, M. Gurrath, G. Müller, H. Kessler, R. Timpl, J. Engel; Selective Recognition of Cyclic RGD Peptides of NMR Defined Conformation by aIIbß3, aVß3 and a5ß1 Integrins. J. Biol. Chem. 1994, 269, 20233-20238.

322.
W. Guba, R. Haeßner, G. Breipohl, S. Henke, J. Knolle, V. Santagada, H. Kessler; A Novel Combined Approach of NMR and Molecular Dynamics within a Biphasic Membrane Mimetic: Conformation and Orientation of the Bradykinin Antagonist Hoe 140; J. Am. Chem. Soc. 1994, 116, 7532-7540.

321.
A. Geyer, G. Müller, H. Kessler; Conformational Analysis of a Cyclic RGD Peptide Containing a y[CH2-NH] Bond: A Positional Shift in Backbone Structure Caused by a Single Dipeptide Mimetic; J. Am. Chem. Soc. 1994, 116, 7735-7743.

320.
R. Haubner, M. Gurrath, G. Müller, M. Aumailley, H. Kessler; Synthetic peptides for the inhibition of cell-cell and cell-matrix adhesion. - in: Prospects in Diagnosis and Treatment of Breast Cancer (Proc. of the Joint International Symposium on Prospects in Diagnosis and Treatment of Breast Cancer, 10-11 November 1993, Munich, Germany) Eds.: M. Schmitt, H. Graeff, G. Kindermann; International Congress Series No. 1050: Excerpta Medica; Elsevier Science B.V. Amsterdam 1994, 133-143.

319.
S. Golic Grdadolnik, D.F. Mierke, G. Byk, I. Zeltser, C. Gilon, H. Kessler; Comparison of the Conformation of Active and Nonactive Backbone Cyclic Analogs of Substance P as a Tool to Elucidate Features of the Bioactive Conformation: NMR and Molecular Dynamics in DMSO and Water; J. Med. Chem. 1994, 37, 2145-2152.

318.
E. Graf von Roedern, H. Kessler; Eine Zuckeraminosäure als neuartiges Peptidmimetikum; Angew. Chem. 1994, 106, 684-686; Angew. Chem. Int. Ed. Engl. 1994, 33, 687-689.

317.
S. Seip, J. Balbach, S. Behrens, H. Kessler, K. Flükiger, R. de Meyer, B. Erni; Mannose Transporter of Escherichia coli. Backbone Assignments and Secondary Structure of the IIA Domain of the IIABMan Subunit; Biochemistry 1994, 33, 7174-7183.

316.
D. F. Mierke, A. Geyer, H. Kessler; Coupling constants and hydrogen bonds as experimental restraints in a distance geometry refinement protocol; Int. J. Pept. Protein Res. 1994, 44, 325-331.

315.
S. Golic Grdadolnik, M. Eberstadt, G. Gemmecker, H. Kessler, A. Buhr, B. Erni; The glucose transporter of Escherichia coli. Assignment of the 1H, 13C and 15N resonances and identification of the secondary structure of the soluble IIB domain; Eur. J. Biochem. 1994, 219, 945-952.

314.
W. Jahnke, D.F. Mierke, L. Béress, H. Kessler; Structure of Cobra Cardiotoxin CTXI as Derived from NMR Spectroscopy and Distance Geometry Calculations, J. Mol. Biol. 1994, 240, 445-458.

313.
D.F. Mierke, T. Huber, H. Kessler; Coupling constants again: Experimental restraints in structure refinement: J. Comp.-Aided Mol. Des. 1994, 8, 29-40.

312.
L. Moroder, R. Romano, W. Guba, D.F. Mierke, H. Kessler, C. Delporte, J. Winand, J. Christophe; New Evidence for a Membrane-Bound Pathway in Hormone Receptor Binding, Biochemistry 1993, 32, 13551-13559.

311.
W. Guba, H. Kessler; A Novel Computational Mimetic of Biological Membranes in Molecular Dynamics Simulations; J. Phys. Chem. 1994, 98, 23-27.

310.
S. Seip, J. Balbach, H. Kessler; Determination of Backbone Conformation of Isotopically Enriched Proteins Based on Coupling Constants; J. Magn. Reson. 1994, B 104, 172-179.

309.
M. Köck, G. Müller, H. Kessler; Computational Approach to the Receptor-Bound Conformation of Cyclosporin A; Helv. Chim. Acta 1994, 77, 171-181.

308.
L. Moroder, R. Romano, J. Winand, J. Christophe, W. Guba, D.F. Mierke, H. Kessler; A comparative study on the physical and conformational state of double-tailed lipo-gastrin and -CCK derivatives. - in: Peptides: Chemistry, Structure and Biology (Proc. of the 13th American Peptide Symposium, June 20-25, 1993, Edmonton, Alberta, Canada) Hrsg.: R.S. Hodges, J.A. Smith; ESCOM Science Publishers, Leiden, The Netherlands 1994, 493-495.

307.
D. F. Mierke, H. Kessler; Solvent simulations and internal motions. - in: Peptides: Chemistry, Structure and Biology (Proc. of the 13th American Peptide Symposium, June 20-25, 1993, Edmonton, Alberta, Canada) Hrsg.: R. S. Hodges, J. A. Smith; ESCOM Science Publishers, Leiden, The Netherlands 1994, 902-904.

306.
D. F. Mierke, H. Kessler; Peptide structures from NMR. - in: Peptides: Chemistry, Structure and Biology (Proc. of the 13th American Peptide Symposium, June 20-25, 1993, Edmonton, Alberta, Canada) Hrsg.: R. S. Hodges, J. A. Smith; ESCOM Science Publishers, Leiden, The Netherlands 1994, 1096-1098.

305.
D. F. Mierke, R. M. Scheek, H. Kessler; Coupling Constants as Restraints in Ensemble Distance Driven Dynamics; Biopolymers 1994, 34, 559-563.

304.
G. Gemmecker, W. Jahnke, H. Kessler; Measurement of Fast Proton Exchange Rates in Isotopically Labeled Compounds; J. Am. Chem. Soc. 1993, 115, 11620-11621.

303.
D. F. Mierke, H. Kessler; Simple modifications of MD force fields for determination of peptide structures from NMR data; in: Trends in QSAR and Molecular Modelling 1992 (Proc. of the 9th European Symposium on Structure-Activity Relationships: QSAR and Molecular Modelling; Sept. 7-11, 1992, Strasbourg, France) Ed.: C.G. Wermuth; ESCOM Science Publishers, Leiden, The Netherlands 1993, 59-66.

302.
W. Schüler, U. Christians, P. Schmieder, H.-M. Schiebel, I. Holze, K.-F. Sewing, H. Kessler; Structural Investigations of 13-O-Demethyl-FK506 and Its Isomers Generated by in vitro Metabolism of FK506 Using Human- Liver Microsomes; Helv. Chim. Acta 1993, 76, 2288- 2302.

301.
D.F. Mierke, M. Kurz, H. Kessler; Peptide Flexibility and Calculations of an Ensemble of Molecules; J. Am. Chem. Soc. 1994, 116, 1042-1049.

300.
A.H. van Oijen, S. Behrens, D.F. Mierke, H. Kessler, J.H. van Boom, R.M.J. Liskamp; Synthesis and Structure of Cyclic Phosphopeptides Containing a Phosphodiester Linkage; J. Org. Chem. 1993, 58, 3722-3730.

299.
V. Wittmann, H. Kessler; Stereoselektive Synthese von C-Glycosiden mit einem Glycosyl-Dianion; Angew. Chem. 1993, 105, 1138-1140; Angew. Chem. Int. Ed. Engl. 1993, 32, 1091-1093.

298.
H. Kessler; Peptoide - Schlüsselverbindungen für einen neuen Weg zur Entwicklung von pharmazeutischen Wirkstoffen; Angew. Chem. 1993, 105, 572-573; Angew. Chem. Int. Ed. Engl. 1993, 32, 543-544.

297.
H. Kessler, H. Matter, G. Gemmecker, H.-J. Diehl, C. Isernia, S. Mronga; The pseudo-ßI-turn. A new structural motif with a cis peptide bond in cyclic hexapeptides; Int. J. Peptide Protein Res. 1994, 43, 47-61.

296.
R. K. Konat, D. F. Mierke, H. Kessler, B. Kutscher, M. Bernd, R. Voegeli; Synthesis and Solvent Effects on the Conformation of Hymenistatin 1; Helv. Chim. Acta 1993, 76, 1649-1666.

295.
S. Zimmer, E. Hoffmann, G. Jung, H. Kessler; 'Head-to-Tail' Cyclization of Hexapeptides Using Different Coupling Reagents; Liebigs Ann. Chem. 1993, 497-501.

294.
M. Gerz, H. Matter, H. Kessler; Synthesis and solution structure of an S- glycosylated cyclic hexapeptide. Evidence for conformational change induced by glycosylation; Int. J. Peptide Protein Res. 1994, 43, 248-257.

293.
L. Moroder, H.-J. Musiol, K. Köcher, J. P. Bali, C. H. Schneider, W. Guba, G. Müller, D. F. Mierke, H. Kessler; Synthetic immunogens. The effect of the conformational space on biological and immunological responses to dimeric hormone constructs; Eur. J. Biochem. 1993, 212, 325-333.

292.
H. Kessler, D. F. Mierke; Conformational Analysis in Solution of Antibiotics with Immunosuppressive Activity. - in: Antibiotics and Antiviral Compounds - Chemical Synthesis and Modification, Hrsg.: K. Krohn, H. A. Kirst, H. Maag; VCH Verlagsgesellschaft, Weinheim 1993, 241-250.

291.
A. Geyer, D. F. Mierke, C. Unverzagt, H. Kessler; Synthesis of cyclic thiohexapeptides. - in: Peptides 1992 (s.o.) Hrsg.: C.H. Schneider, A.N. Eberle; ESCOM Science Publishers, Leiden, The Netherlands, 1993, 599-600.

290.
M. Köck, G. Müller, H. Kessler; Structure-activity relationship of cyclosporin A using dynamic forcing. - in: Peptides 1992 (s.o.) Hrsg.: C.H. Schneider, A.N. Eberle; ESCOM Science Publishers, Leiden, The Netherlands, 1993, 511-512.

289.
S. Zimmer, E. Hoffmann, G. Jung, H. Kessler; Synthesis and backbone cyclization studies of hexapeptides using the reagents TBTU, HBTU, DPPA, and PPA. - in: Peptides 1992 (s.o.) Hrsg.: C.H. Schneider, A.N. Eberle; ESCOM Science Publishers, Leiden, The Netherlands, 1993, 393- 394.

288.
V. Wittmann, H. Kessler; Synthesis of C-glycosyl amino acids and their use in SPPS. - in: Peptides 1992 (s.o.) Hrsg.: C.H. Schneider, A.N. Eberle; ESCOM Science Publishers, Leiden, The Netherlands, 1993, 369- 370.

287.
H. Kessler, M. Gurrath, G. Müller, M. Aumailley, R. Timple; Selective RGD peptides for inhibition of cell-cell interactions via backbone cyclization. - in: Peptides 1992 (Proc. of the 22nd European Peptide Symposium, Interlaken, Switzerland, September 13-19, 1992) Hrsg.: C.H. Schneider, A.N. Eberle; ESCOM Science Publishers, Leiden, The Netherlands, 1993, 75-76.

286.
S. Seip, J. Balbach, H. Kessler; A simple way for sequential assignment in isotopically enriched proteins using a H(N)CACO correlation; J. Biomol. NMR 1993, 3, 233-237.

285.
S. Seip, J. Balbach, H. Kessler; Bestimmung der HN-Ha Kopplungskonstanten in großen, isotopenmarkierten Proteinen; Angew. Chem. 1992, 104, 1656-1658; Angew. Chem. Int. Ed. Engl. 1992, 31, 1609-1611.

284.
M. Eberstadt, D. F. Mierke, M. Köck, H. Kessler; Peptide Conformation from Coupling Constants: Scalar Couplings as Restraints in MD Simulations; Helv. Chim. Acta 1992, 75, 2583- 2592.

283.
D. F. Mierke, H. Kessler; Improved Molecular Dynamics Simulations for the Determination of Peptide Structures; Biopolymers 1993, 33, 1003-1017.

282.
M. Gerz, H. Matter, H. Kessler; S-glycosylierte Cyclopeptide; Angew. Chem. 1993, 105, 311-313; Angew. Chem. Int. Ed. Engl. 1993, 32, 269-271.

281.
M. Gurrath, G. Müller, H. Kessler, M. Aumailley, R. Timpl; Conformation/activity studies of rationally designed potent anti-adhesive RGD peptides; Eur. J. Biochem. 1992, 210, 911- 921.

280.
A. E. Torda, R. M. Brunne, T. Huber, H. Kessler, W. F. van Gunsteren; Structure refinement using time-averaged J-coupling constants restraints; J. Biomol. NMR 1993, 3, 55-66.

279.
H. Kessler, R. Haessner, W. Schüler; Structure of Rapamycin: An NMR and Molecular-Dynamics Investigation; Helv. Chim. Acta 1993, 76, 117-130.

278.
P. Schmieder, J. H. Ippel, H. van den Elst, G. A. van der Marel, J. H. van Boom, C. Altona, H. Kessler; Heteronuclear NMR of DNA with the heteronucleus in natural abundance: Facilitated assignment and extraction of coupling constants; Nucleic Acids Res. 1992, 20, 4747-4751.

277.
H. Kessler, S. Seip; NMR of Peptides - in: Two-Dimensional NMR Spectroscopy: Applications for Chemists and Biochemists (Eds.: W.R. Croasmun, R.M.K. Carlson) VCH Publishers, New York, 1994, 619- 654.

276.
H. Kessler; Struktur und Design von Cyclopeptiden zur Regulation des Immunsystems; J. prakt. Chem. 1992, 334, 549- 557.

275.
D. F. Mierke, S. Golic Grdadolnik, H. Kessler; Use of One Bond Ca-Ha Coupling Constants As Restraints in MD Simulations; J. Am. Chem. Soc. 1992, 114, 8283-8284.

274.
S. Seip, J. Balbach, H. Kessler; An Improved Technique for Correlating Backbone Amide Protons with 15N and Ha Protons (HN(CA)H) in Isotopically Enriched Proteins; J. Magn. Reson. 1992, 100, 406-410.

273.
C. Unverzagt, A. Geyer, H. Kessler; Racemisierungsfreie Kettenverlängerung von Thiodipeptiden mit Proteasen; Angew. Chem. 1992, 104, 1231-1233; Angew. Chem. Int. Ed. Engl. 1992, 31, 1229-1230.

272.
G. Müller, M. Gurrath, M. Kurz, H. Kessler; ßVI Turns in Peptides and Proteins. A Model Peptide Mimicry; Proteins: Structure, Function, and Genetics 1993, 15, 235-251.

271.
H. Kessler, V. Wittmann, M. Köck, M. Kottenhahn; Synthese von C-Glycopeptiden durch radikalische Addition von Glycosylbromiden an Dehydroalaninderivate; Angew. Chem. 1992, 104, 874-877; Angew. Chem. Int. Ed. Engl. 1992, 31, 902-904.

270.
D.F. Mierke, H. Dürr, H. Kessler, G. Jung; Neuropeptide Y: Optimized Solid Phase Synthesis and Conformational Analysis in Trifluoroethanol; Eur. J. Biochem. 1992, 206, 39-48.

269.
D.F. Mierke, H. Kessler; Combined Use of Homo- and Heteronuclear Coupling Constants as Restraints in Molecular Dynamics Simulations; Biopolymers 1992, 32, 1277-1282.

268.
H. Kessler, H. Matter, A. Geyer, H.-J. Diehl, M. Köck, G. Kurz, F.R. Opperdoes, M. Callens, R.K. Wierenga; Selektive Inhibierung der trypanosomalen Triosephosphat-Isomerase durch ein Thiopeptid; Angew. Chem. 1992, 104, 343-345; Angew. Chem. Int. Ed. Engl. 1992, 31, 328-330.

267.
L. Moroder, K. Köcher, H.-J. Musiol, W. Guba, G. Müller, H. Kessler; The Conformational Space of Conjugated Peptide Hormones Affects Critically Their Bioactivity and Immunoreactivity; - in: The Fourth Akabori Conference (Proc. of the 4th Akabori Conference, Japanese-German Symposium on Peptide Chemistry, Shizuoka/Japan, Oct. 7-10, 1991) (Hrsg.: N. Yanaihara, E. Wünsch) Protein Research Foundation, Osaka, Japan, 1992, 191-200.

266.
M. Gurrath, G. Müller, H. Kessler, R. Timpl, M. Aumailley; Structure and Conformation-Activity Studies Leading to Potent RGD Containing Vitronectin and Laminin P1 Antagonists; - in: s. Nr. 265. Verlag Mainz, Aachen, DWI Reports, 1993, 112A, 489-498.

265.
G. Müller, M. Gurrath, H. Kessler, R. Timpl, M. Aumailley; Conformational Analysis and Structure-Activity Relationships of Bioactive RGD (Arg-Gly-Asp) Peptides. A Computational Approach; - in: Chemistry of Peptides and Proteins (Vol. 5/6) (Proc. 7th USSR-FRG Symp. on Chemistry of Peptides and Proteins, Dilizhan, USSR, Sept. 23-30, 1989 and 8th FRG-USSR Symp. Aachen, FRG, 29.9.-3.10.1991) Hrsg.: D. Brandenburg, V. Ivanov, W. Voelter; Verlag Mainz, Aachen, DWI Reports, 1993, 112A, 499-511.

264.
G. Müller, M. Gurrath, H. Kessler, R. Timpl; "Dynamischer Zwang", eine Hilfe für das Verständnis der Aktivität und Selektivität von RGD(Arg-Gly-Asp)-Peptiden; Angew. Chem. 1992, 104, 341-343; Angew. Chem. Int. Ed. Engl. 1992, 31, 326-328.

263.
H. Kessler, A. Geyer, H. Matter, M. Köck; Unusual Thionation of a Cyclic Hexapeptide. Conformational Changes and Dynamics; Int. J. Pept. Prot. Res. 1992, 40, 25-40.

262.
M. Köck, H. Kessler, D. Seebach, A. Thaler; Novel Backbone Conformation of Cyclosporin A: The Complex with Lithium Chloride; J. Am. Chem. Soc. 1992, 114, 2676-2686.

261.
M. Kurz, D.F. Mierke, H. Kessler; Moleküldynamikrechnungen für Peptide in Dimethylsulfoxid: Eliminierung von Vakuumeffekten; Angew. Chem. 1992, 104, 213-214; Angew. Chem. Int. Ed. Engl. 1992, 31, 210-212.

260.
H. Kessler, S. Mronga, B. Kutscher, A. Müller, W.S. Sheldrick; Synthesis of the 4-Pyridine Analog of Kostanecki's Triketone. Determination of Constitution and Stereochemistry by 2D-NMR Spectroscopy and X-ray Structural Analysis; Liebigs Ann. Chem. 1991, 1337-1341.

259.
D. Seebach, S.Y. Ko, H. Kessler, M. Köck, M. Reggelin, P. Schmieder, M.D. Walkinshaw, J.J. Bölsterli, D. Bevec; Thiocyclosporins: Preparation, Solution and Crystal Structure, and Immunosuppressive Activity; Helv. Chim. Acta 1991, 74, 1953-1990.

258.
M. Aumailley, M. Gurrath, G. Müller, J. Calvete, R. Timpl, H. Kessler; Arg-Gly-Asp constrained within cyclic pentapeptides: strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1; FEBS Lett. 1991, 291, 50-54.

257.
H. Kessler, D.F. Mierke, J. Saulitis, S. Seip, S. Steuernagel, T. Wein, M. Will; The Structure of Ro 09-0198 in Different Environments; Biopolymers 1992, 32, 427-433.

256.
P. Schmieder, H. Kessler; Determination of the f Angle in a Peptide Backbone by NMR Spectroscopy with a Combination of Homonuclear and Heteronuclear Coupling Constants; Biopolymers 1992, 32, 435-440.

255.
M. Kurz, P. Schmieder, H. Kessler; HETLOC, eine effiziente Methode zur Bestimmung heteronuclearer Weitbereichskopplungen mit dem Heterokern in natürlicher Häufigkeit; Angew. Chem. 1991, 103, 1341-1342; Angew. Chem. Int. Ed. Engl. 1991, 30, 1329-1331.

254.
H. Kessler, B. Haase; Cyclic hexapeptides derived from the human thymopoietin III; Int. J. Pept. Prot. Res. 1992, 39, 36-40.

253.
H. Kessler, S. Seip, T. Wein, S. Steuernagel, M. Will; Structure of cinnamycin (Ro 09-0198) in solution; - in: Nisin and Novel Lantibiotics (Proc. 1th Int. Workshop on Latibiotics, April 1991, Bad Honnef) (Hrsg: G. Jung, H.G. Sahl) ESCOM, Leiden, 1991, 76-90.

253.
G. Bitan, S. Behrens, B. Mathä, Y. Mashriki, M. Hanani, H. Kessler, C. Gilon; New backbone cyclic substance P analogs; Lett. Pept. Sci. 1995, 2, 121-124.

252.
D.F. Mierke, P. Schmieder, P. Karuso, H. Kessler; Conformational Analysis of the cis- and trans-Isomers of FK 506 by NMR and Molecular Dynamics; Helv. Chim. Acta 1991, 74, 1027-1047.

251.
P. Schmieder, M. Kurz, H. Kessler; Determination of heteronuclear long-range couplings to heteronuclei in natural abundance by two- and three-dimensional NMR spectroscopy; J. Biomol. NMR 1991, 1, 403-420.

250.
H. Kessler, D.F. Mierke, D. Donald, M. Furber; Auf dem Weg zum Verständnis der Immunsuppression; Angew. Chem. 1991, 103, 968-969; Angew. Chem. Int. Ed. Engl. 1991, 30, 954-955.

249.
J. Saulitis, D.F. Mierke, G. Byk, C. Gilon, H. Kessler; Conformation of Cyclic Analogues of Substance P: NMR and Molecular Dynamics in Dimethyl Sulfoxide; J. Am. Chem. Soc. 1992, 114, 4818-4827.

248.
H. Kessler, H. Matter, G. Gemmecker, M. Kottenhahn, J.W. Bats; Structure and Dynamics of a Synthetic O-Glycosylated Cyclopeptide in Solution Determined by NMR Spectroscopy and MD Calculations; J. Am. Chem. Soc. 1992, 114, 4805-4818.

247.
D.A. Kuntz, R. Osowski, M. Schudok, R.K. Wierenga, K. Müller, H. Kessler, F.R. Opperdoes; Inhibition of triosephosphate isomerase from Trypanosoma brucei with cyclic hexapeptides; Eur. J. Biochem. 1992, 207, 441-447.

246.
W. Guba, G. Müller, H. Kessler; Rational drug design via molecular dynamics simulations of HIV-1 protease inhibitor complexes; J. Chim. Phys. 1991, 88, 2551-2556.

245.
D.F. Mierke, H. Kessler; Molecular Dynamics with Dimethyl Sulfoxide as a Solvent. Conformation of a Cyclic Hexapeptide; J. Am. Chem. Soc. 1991, 113, 9566-9470.

244.
H. Kessler, S. Mronga, G. Gemmecker; Multi-Dimensional NMR Experiments Using Selective Pulses; Magn. Reson. Chem. 1991, 29, 527-557.

243.
H. Kessler, S. Mronga, G. Müller, L. Moroder, R. Huber; Conformational Analysis of a IgG1 Hinge Peptide Derivative in Solution Determined by NMR Spectroscopy and Refined by Restrained Molecular Dynamics Simulations; Biopolymers 1991, 31, 1189-1204.

242.
H. Kessler, H. Matter, G. Gemmecker, A. Kling, M. Kottenhahn; Solution Structure of a Synthetic N-Glycosylated Cyclic Hexapeptide Determined by NMR Spectroscopy and MD Calculations; J. Am. Chem. Soc. 1991, 113, 7550-7563.

241.
M. Kottenhahn, H. Kessler; Synthese von 2-Desoxy-a-O-glycopeptiden mit dem N-Iodsuccinimid-(NIS-)Verfahren; Liebigs Ann. Chem. 1991, 727-744.

240.
H. Kessler, S. Seip, J. Saulitis; Determination of cross relaxation rates by 3D NOE-NOE spectroscopy; J. Biomol. NMR 1991, 1, 83-92.

239.
P. Schmieder, T. Domke, D.G. Norris, M. Kurz, H. Kessler, D. Leibfritz; Editing of Multiplicity in Two- and Three-Dimensional Heteronuclear NMR Spectroscopy by Fourier Transformation of the Pulse-Angle Dependency; J. Magn. Reson. 1991, 33, 430-435.

238.
P. Schmieder, S. Zimmer, H. Kessler; Increased Resolution in Proton Detected Heteronuclear NMR Experiments by Folding in the Hetero-Dimension; Magn. Reson. Chem.1991, 29, 375-380.

237.
H. Kessler, T. Wein; Solution Structure of Phalloidin Obtained by NMR Spectroscopy in [D6]DMSO and Molecular Dynamics Calculation in Vacuo and in Water; Liebbigs Ann. Chem. 1991, 179-184.

236.
H. Kessler, M. Köck, T. Wein, M. Gehrke; Reinvestigation of the Conformation of Cyclosporin A in Chloroform; Helv. Chim. Acta 1990, 73, 1818-1832.

235.
P. Karuso, H. Kessler, D.F. Mierke; Solution Structure of FK 506 from NMR and Molecular Dynamics; J. Am. Chem. Soc. 1990, 112, 9434-9436.

234.
H. Kessler, P. Schmieder; Heteronuclear Two- and Three-Dimensional NMR Spectroscopy of 13C in Natural Abundance by Multiplicity Selection and Editing: Application to Peptides; Biopolymers 1991, 31, 621-629.

233.
H. Kessler, P. Schmieder, H. Oschkinat; 3D Heteronuclear NMR Techniques for Carbon-13 in Natural Abundance; J. Am. Chem. Soc. 1990, 112, 8599-8600.

232.
H. Kessler, P. Schmieder, M. Köck, M. Reggelin; Selection of Methyl Resonances in Proton-Detected Heteronuclear Shift Correlation, the HQQC Experiment; J. Magn. Reson. 1991, 91, 375-379.

231.
H. Kessler, S. Mronga, G. Gemmecker; Zero-Quantum Spectroscopy with TOCSY Transfer; J. Magn. Reson. 1990, 87, 633-638.

230.
P. Schmieder, H. Kessler, H. Oschkinat; Schnelle Heterokern-3D-NMR-Spektroskopie; Angew. Chem. 1990, 102, 588-589; Angew. Chem. Int. Ed. Engl. 1990, 29, 546-548.

229.
H. Kessler, U. Anders, M. Schudok; An Unexpected Cis Peptide Bond in the Minor Conformation of a Cyclic Hexapeptide Containing Only Secondary Amide Bonds; J. Am. Chem. Soc. 1990, 112, 5908-5916.

228.
H. Kessler, P. Schmieder, M. Köck, M. Kurz; Improved Resolution in Proton-Detected Heteronuclear Long-Range Correlation; J. Magn. Reson. 1990, 88, 615-618.

227.
H. Kessler, M. Schudok; Short and Efficient Synthesis of Statine and Isostatine-Derivatives; Synthesis 1990, 457-458.

226.
H. Kessler, A. Kling, M. Kottenhahn; Einfache Synthese eines ß(1-3)-verknüpften gal-galactal-Disaccharids und dessen Verwendung in der N-Iodsuccinimid-aktivierten O-Glycopeptid-synthese; Angew. Chem. 1990, 102, 452-454; Angew. Chem. Int. Ed. Engl. 1990, 29, 425-427.

225.
H. Kessler, S. Mronga, M. Will, U. Schmidt; Solution Structure of [Me-L-Leu7] Didemnin B Determined by NMR-Spectroscopy and Refined by MD Calculation; Helv. Chim. Acta 1990, 73, 25-47.

224.
H. Kessler, P. Schmieder, W. Bermel; Complete Assignment of the Noncarbonylic Carbon-13 Resonances of Tendamistat; Biopolymers 1990, 30, 465-475.

223.
H. Kessler, M. Kottenhahn, A. Kling, H. Matter; Synthesis and Conformational Studies of O-Glycopeptides (Proc. 3rd Akabori Conf., German-Japanese Symp. on Peptide Chemistry, Prien/Chiemsee 1989) (Hrsg.: E. Wünsch) Max-Planck-Inst. für Biochemie, Martinsried, 1989, 45-49.

222.
H. Kessler, S. Seip, S. Steuernagel, M. Will, D. Gillessen, T. Kamiyama; The Antibioticum RO 09-0198, a Molecule with Two Different Active Sites; - in: Chemistry of Peptides and Proteins (Vol. 5/6) (Proc. 7th USSR-FRG Symp. on Chemistry of Peptides and Proteins, Dilizhan/USSR, Sept. 23-30, 1989 and 8th FRG-USSR Symp., Aachen, 29.9.-3.10.1991) (Hrsg: D. Brandenburg, V. Ivanov, W. Voelter) Verlag Mainz, Aachen, DWI Reports 1993.

221.
H. Kessler; Peptide Engineering: Design of Biologically Active Peptides under Conformational Control; - in: Trends in Drug Research (Proc. 7th Noordwijkerhout-Camerino Symposium, The Netherlands, 1989) (Hrsg.: V. Claassen) Elsevier Science Publishers, Amsterdam, 1990, 73-84.

220.
H. Kessler, M. Gehrke, J. Lautz, M. Köck, D. Seebach, A. Thaler; Complexation and medium effects on the conformation of cyclosporin A studied by NMR spectroscopy and MD calculations; Biochem. Pharmacol. 1990, 40, 169-173.

219.
H. Kessler, G. Gemmecker, M. Köck, R. Osowski, P. Schmieder; Improvement of Carbon-Detected H,H-TOCSY Experiments by Employing a DEPT Transfer; J. Magn. Reson. 1990, 28, 62-67.